Global knock-out of Atp11b model

Overview: Species

Rat

Strain common name

Atp11bKO

Full nomenclature

Atp11bKO

Genetic background

Sprague Dawley

Description of model, including genes and any mutation(s):

Global knock-out of Atp11b

Original publication of model

DOI: 10.1007/s00401-022-02441-4

Breeding scheme

Normal

Type of model

Small vessel disease
Availability: Principal investigator

Anna Williams

Institution

University of Edinburgh

Named contact

Anna Williams

Contact email

anna.williams@ed.ac.uk

Source of model

In-house

Supplier code

-

MTA Holder and Issuing Organisation:

-
Study details: Sex

Both

Age of model

Young, juvenile, adult

Duration of Study

Up to about 40 weeks so far published

Diet

Standard chow

Cage enrichment and housing

Group housing

Types of outcomes measured

Neurobehaviour (i.e. sensory, motor, cognition)

Physiology (i.e. body weight, BP)

Structural measure (i.e. IHC, EM, structural MRI)

Vascular function (i.e. BBB integrity, CBF)

Details of Outcomes Measured

Structure (histology, EM), behaviour (open field, elevated maze, NOR, catwalk), MRI, physiology, BP

Strengths of Model

- Highly relevant to human sporadic small vessel disease histologically cognitively and by gait
- Not hypertensive - demonstrates that SVD can occur without hypertension.
- Not classed as severe by home office.

Limitations of Model

- Changes are present but not overtly having strokes.
- Probably other genes can be involved