- Overview
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Species
RatStrain common name
SHRSPFull nomenclature
Spontaneously hypertensive stroke prone ratGenetic background
Wistar-KyotoDescription of model, including genes and any mutation(s):
Inbred strain derived from Wistar Kyoto, spontaneously develop hypertension and increased risk of stroke (haemorrhagic)
Original publication of model
-Breeding scheme
-Type of model
Ischemic stroke - Availability
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Principal investigator
Lorraine WorkInstitution
University of GlasgowNamed contact
Lorraine WorkContact email
Lorraine.Work@glasgow.ac.ukSource of model
In-houseSupplier code
-MTA Holder and Issuing Organisation:
- - Intervention details
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Intervention
OcclusionStandard Operating Procedures for Intervention
https://drive.google.com/open?id=1ouVJoF1TEgOTCErwud8DE1KtdrpqiIC_Age at Surgery
18-22 weeksAnaesthetic
Isoflurane in oxygenAnalgesics
Naroprin at incision siteAntibiotics
-Duration of occlusion is temporary
Method for inducing the occlusion is mechanical
Method for inducing the occlusion is filament
- Study details
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Sex
MaleAge of model
18-22 weekDuration of Study
Typically 24hrs - 2 weeksDiet
Standard chowCage enrichment and housing
House singly after stroke procedureTypes of outcomes measured
Neurobehaviour (i.e. sensory, motor, cognition)Omics (i.e transcriptomics, proteomics, metabolomics)Physiology (i.e. body weight, BP)Structural measure (i.e. IHC, EM, structural MRI)Details of Outcomes Measured
Neurological Deficit Score (NDS), tapered beam score, sticky label removal, NOR, Y maze, miRNA profiling
Standard Operating Procedures for Intervention
https://drive.google.com/open?id=1ouVJoF1TEgOTCErwud8DE1KtdrpqiIC_
Image
Ischaemic stroke of cortical and subcortical regions model
Vascular cognitive impairment (i.e. chronic hypoperfusion)