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Lancet Digit Health
Published

Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis.

Authors

Smruthy Sivakumar, Jessica K Lee, Jay A Moore, Julia Hopkins, Justin Y Newberg, Russell Madison, Ryon Graf, Alexa B Schrock, Erin Kobetz, Randy Vince, Idalid Franco, Crystal Seldon, Garrett M Frampton, Jennifer Mills, Jeffrey Venstrom, Brandon A Mahal

Abstract

Men of African ancestry experience the greatest burden of prostate cancer globally, but they are under-represented in genomic and precision medicine studies. Therefore, we sought to characterise the genomic landscape, comprehensive genomic profiling (CGP) utilisation patterns, and treatment patterns across ancestries in a large, diverse, advanced prostate cancer cohort, to determine the impact of genomics on ancestral disparities.

PMID:37236698 | DOI:S2589-7500(23)00053-5