Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
Authors
Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Carmen Arteaga Reyes, Daniela Jaime Garcia, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Agniete Kampaite, Marco Duering, Julie Staals, Saskia Lesnik-Oberstein, Keith W Muir, Martin Middeke, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair J S Webb, Joanna M Wardlaw, Martin Dichgans
Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease.
Identifying the mechanisms that drive brain haemorrhages in CAA, with a broader interest in shared disease mechanisms across cerebral small vessel diseases.
