JCO Precis Oncol
Published

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response.

Authors

Jay A Moore, Kuei-Ting Chen, Russell Madison, Justin Y Newberg, Zoe Fleischmann, Shuoguo Wang, Radwa Sharaf, Karthikeyan Murugesan, Bernard J Fendler, Jason Hughes, Alexa B Schrock, Priti S Hegde, Geoffrey R Oxnard, David Fabrizio, Garrett M Frampton, Emmanuel S Antonarakis, Ethan S Sokol, Dexter X Jin
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Abstract

Copy-number (CN) features reveal the molecular state of cancers and may have predictive and prognostic value in the treatment of cancer. We sought to apply published CN analysis methods to a large pan-cancer data set and characterize ubiquitous CN signatures across tumor types, including potential utility for treatment selection.

PMID:37769224 | DOI: