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Trends in neurosciences
Published

A timeline of tau-mediated synaptotoxicity

Authors

Calum K Bonthron, Claire S Durrant

Abstract

Trends Neurosci. 2026 Apr 11:S0166-2236(26)00057-3. doi: 10.1016/j.tins.2026.03.011. Online ahead of print.

ABSTRACT

Oligomeric tau has been increasingly implicated in synaptic impairments observed in Alzheimer's disease. In a recent study, Pareja-Navarro and colleagues provide insights into the precise timeline of synaptic deficits induced by oligomeric forms of tau. Such knowledge could aid in the design of therapeutic interventions to prevent synaptic loss.

PMID:41968010 | DOI:10.1016/j.tins.2026.03.011