Amanda Heslegrave

Dr Amanda Heslegrave

Principal Research Fellow

Co-leading the UK DRI Biomarker Factory platform based at UK DRI at UCL

Biography

Dr. Amanda Heslegrave is Principal Research Fellow at the UK DRI at UCL, where she co-leads the fluid biomarker (Zetterberg) laboratory and the UK DRI Biomarker Factory. After completing her BSc from Birkbeck, University of London (2000) and PhD from UCL (2005), she transitioned to biomarker research in 2012 with Prof Henrik Zetterberg at UCL. Her research focuses on fluid biomarkers in CSF and blood, utilising immunoassay and proteomic methods to study neurodegenerative diseases. 

News

Key publications

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Mind the gap: obtaining reliable sleep estimates and the diagnostic value of sleep discrepancy in individuals with Alzheimer's disease and Lewy body disease

Authors
Victoria Grace Gabb, Jonathan Blackman, Hamish Duncan Morrison, Nicholas Turner, Amanda Heslegrave, Elizabeth Coulthard
Mind the gap: obtaining reliable sleep estimates and the diagnostic value of sleep discrepancy in individuals with Alzheimer's disease and Lewy body disease
HIV medicine
Published

Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART

Authors
Merle Henderson, Peter Dutey-Magni, Carolina Herrera, Wolfgang Stöhr, Alejandro Arenas-Pinto, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, John Tregoning, Sarah Fidler, François Raffi, Andrea Calcagno, Ab Babiker, Alan Winston
Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART
Neuron
Published

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
Brain communications
Published

Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay

Authors
Nirosen Vijiaratnam, Christine Girges, Arthur Mitchell, Dilan Athauda, Riona Fumi, Jennifer Hay, Nicola O'Reilly, Huw Morris, Camille Carroll, Michele T M Hu, Monty A Silverdale, Gordon Duncan, Amanda Heslegrave, Eliza Chai, Sonia Gandhi, Thomas Foltynie
Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay

The Biomarker Factory

Dr Amanda Heslegrave co-leads the UK DRI Biomarker Factory, transforming the early detection, diagnosis and monitoring of dementia, by facilitating the development of fluid biomarkers for research and the clinic

UK DRI Biomarker Factory
Scientists posing in the lab in white coats