Jernej Ule profile

Prof Jernej Ule

Centre Director

Deciphering the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia

Condition

Alzheimer's disease, Motor neuron disease/ALS, Frontotemporal dementia

Topics

Ageing, Cell biology of neurons & glia, Molecular mechanisms, Sleep & Circadian rhythms, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Advanced spectroscopy, Bioinformatics, Biophysical techniques, CRISPR, Epigenomics, Flow cytometry, Genomics, Mass spec-based proteomics, Next generation sequencing, Single cell / nucleus transcriptomics, Software development, Spatial transcriptomics, Stem cells / iPSCs

Biography

Jernej Ule obtained his BSc in Molecular Biology from University of Ljubljana, Slovenia and then went on to complete a PhD and postdoctoral programme with Dr Robert Darnell at The Rockefeller University (New York) before starting his own research group at the MRC Laboratory of Molecular Biology (Cambridge) in July 2006. He then moved with his team to the UCL Queen Square Institute of Neurology (London) and started a secondment as a Group Leader at the Francis Crick Institute. In April 2022, Prof Ule was appointed as Director of the UK DRI at King’s, where most of his team is now located. He also maintains a joint satellite team at the Francis Crick Institute with Prof Benjamin Blencowe to conduct research funded by the Wellcome Trust.

News

Key publications

Science (New York, N.Y.)
Published
Creation of de novo cryptic splicing for ALS and FTD precision medicine
Authors
Oscar G Wilkins, Max Z Y J Chien, Josette J Wlaschin, Simone Barattucci, Peter Harley, Francesca Mattedi, Puja R Mehta, Maria Pisliakova, Eugeni Ryadnov, Matthew J Keuss, David Thompson, Holly Digby, Lea Knez, Rebecca L Simkin, Juan Antinao Diaz, Matteo Zanovello, Anna-Leigh Brown, Annalucia Darbey, Rajvinder Karda, Elizabeth M C Fisher, Thomas J Cunningham, Claire E Le Pichon, Jernej Ule, Pietro Fratta
Creation of de novo cryptic splicing for ALS and FTD precision medicine
Nature communications
Published
NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity
Authors
Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R Poetsch, Maria Victoria Botuyan, Gaofeng Cui, Georges Mer, Jernej Ule, Pascal Drané, Dipanjan Chowdhury
NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

Ule Lab

Explore the work of the Ule Lab focused on understanding the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia.

Ule Lab
RNA