Prof Marc-David Ruepp

Group Leader

Exploring RNA metabolism in health and neurodegeneration

Condition

Frontotemporal dementia, Motor neuron disease/ALS

Topics

Cell biology of neurons & glia, Molecular mechanisms

Techniques

Advanced microscopy & imaging, CRISPR, Biophysical techniques, Next generation sequencing, Stem cells / iPSCs, Viral-mediated expression

Biography

Marc-David Ruepp is a Professor of RNA Biology and Molecular Neurodegeneration at the UK Dementia Research Institute (UK DRI) at King’s College London. His laboratory is interested in RNA metabolism in health and disease with a specific focus on neurodegeneration. He received his PhD in 2009 (Graduate School of Cellular and Biomedical Sciences, University of Bern) and started his independent scientific career as Junior Group Leader in 2014 in the Department of Chemistry and Biochemistry at the University of Bern, Switzerland. He habilitated at the Faculty of Science, University of Bern, and received his Venia Docendi in RNA biology in 2018. The same year he joined the UK DRI as Group Leader and King’s College London as Senior Lecturer in Neuroscience. In 2022 he was promoted to Reader and in 2025 to Professor of RNA Biology and Molecular Neurodegeneration.

News

- Research

Faulty cellular ‘energy supply’ in ALS

Two common types of gene mutation in amyotrophic lateral sclerosis (ALS) have been linked to...

Learn more Faulty cellular ‘energy supply’ in ALS

Key publications

Nature communications
Published
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
Authors
Rebecca Casterton, Aitana Martinez-Cotrina, Jodi Barnard, Eleanor Wycherley, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Olivia Houghton, Daniel A Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
bioRxiv : the preprint server for biology
Published
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity
Authors
Noah Wake, Juan Alcalde, Daniel Jutzi, Anjali Bajaj, Sukhleen Kour, Mayur Barai, Shuo-Lin Weng, Samara Cummings, Tongyin Zheng, Eric N Anderson, Szu-Huan Wang, Ryan Puterbaugh, Daryl A Bosco, Benjamin S Schuster, Jeetain Mittal, Udai Bhan Pandey, Marc-David Ruepp, Nicolas L Fawzi
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity
bioRxiv : the preprint server for biology
Published
U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis
Authors
Puja R Mehta, Tomas Solomon, Sarah Pickles, Peter Harley, Michela Barioglio, Christoph Schweingruber, Alessandro Marrero-Gagliardi, Yujing Gao, Francesca Mattedi, Simone Barattucci, Lilian Tsai-Wei Lin, Eugeni Ryadnov, Matteo Zanovello, Alexander J Cammack, Adrian M Isaacs, Juan Burrone, Christopher E Shaw, Matthew J Keuss, Leonard Petrucelli, Pietro Fratta, Marc-David Ruepp
U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis
bioRxiv : the preprint server for biology
Published
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Authors
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel E Rech, Michael Flower, Niamh O'Brien, Marc-David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J Tabrizi, Elizabeth M C Fisher, Thomas J Cunningham, Michael Ward, William C Skarnes, Adrian M Isaacs
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD

Ruepp Lab

Explore the work of the Ruepp Lab, exploring RNA metabolism in health and disease with a specific focus on neurodegeneration

Ruepp Lab
Cytoplasmic mutant TAF15 engulfs U12 snRNAs in the cytoplasm of HeLa cells