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Axel Montagne

Dr Axel Montagne

PhD ((he/him))

Group Leader

Exploring the link between cerebrovascular and inflamm-ageing to neurodegeneration and dementia

Techniques

Advanced microscopy & imaging, Bioinformatics, Fluid biomarkers, Human brain imaging, Mass spec-based proteomics, Mouse behaviour, Mouse in vivo imaging, Next generation sequencing, Single cell / nucleus transcriptomics, Software development, Spatial transcriptomics, Viral-mediated expression

Biography

Dr Axel Montagne joined the UK Dementia Research Institute at Edinburgh in 2020. 

He completed his PhD degree at the University of Caen Normandy (France), followed by postdoctoral training at the University of Southern California (USC) in Los Angeles. Axel rapidly became Assistant and then Associate Professor at USC in 2016 and 2020, respectively. 

His career has focused on how cerebrovascular dysfunctions contribute to neurodegeneration and dementia in both animal models and humans. 

In his UK DRI program, he combines molecular approaches with rodent non-invasive imaging, particularly MRI and microscopy techniques, to study the causes and effects of blood-brain barrier (BBB) dysfunction, with a particular focus on the Endothelium-Pericyte-Immune tripartite interactions, in the context of neurodegenerative disease. 

Dr Montagne was awarded the 2021 SCOR Young European Researcher Prize for his research into Alzheimer’s disease and a MRC Career Development Award in 2022. Dr Montagne was featured in the prestigious Highly Cited Researcher list from Clarivate in 2022 and 2023.

News

Key publications

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Basic Science and Pathogenesis
Authors
Krystal K Laing, Audrey Chagnot, Ross Lennen, Bethany Geary, William Mungall, Joanna M Wardlaw, Axel Montagne
Basic Science and Pathogenesis
EJNMMI physics
Published
Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET
Authors
Dániel Réti, Carlos-Alcaide Corral, Islay Cranston, Victoria J M Reid, Kerry M O'Rourke, Timaeus E F Morgan, Axel Montagne, Maurits A Jansen, Valeria K Burianova, Andrew Sutherland, Péter Major, Kálmán Nagy, Gergő Bagaméry, Adriana A S Tavares
Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET
Current biology : CB
Published
The blood-brain barrier
Authors
Audrey Chagnot, Axel Montagne
The blood-brain barrier

Montagne Lab

Explore the work of the Montagne Lab focused on exploring the cerebrovascular and inflamm-ageing link to neurodegeneration and dementia.

Congestions Montagne Lab