Mol Neurodegener
Published

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.

Authors

Kathryn R Bowles, Derian A Pugh, Yiyuan Liu, Tulsi Patel, Alan E Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D Cherry, Celeste M Karch, Steven J Frucht, Brian H Kopell, Inga Peter, Y J Park, , Alexander Charney, Towfique Raj, John F Crary, A M Goate
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Abstract

Parkinson's disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified.

PMID:35841044 | DOI:10.1186/s13024-022-00551-x