Abstract
Alzheimers Dement. 2026 Nov;22(11):e71949. doi: 10.1002/alz.71949.
ABSTRACT
INTRODUCTION: Dementia prevention research increasingly uses multimodal interventions. Harmonized biomarker practices are essential to enable comparable cross-population analysis with initiatives such as the World-Wide FINGERS (WW-FINGERS) network contributing to this effort.
METHODS: To advance globally representative biomarker research in dementia prevention trials, we conducted a cross-sectional, network-wide survey of WW-FINGERS teams assessing biospecimen collection, processing and storage, biomarker measurements, and readiness for harmonized procedures.
RESULTS: Most studies (30/39) had or were developing biorepositories; four planned collection and five had none. Practices were broadly aligned, but remaining variability highlights priority targets for harmonization. Clinical biomarkers (lipids, glucose, liver/kidney function) were obtained even in lower-resourced settings. Many studies measured Alzheimer's disease and related dementias (ADRD) biomarkers (blood-based amyloid/tau and neurodegeneration; cerebrospinal fluid where feasible) and increasingly used multi-omics platforms. Evidence-based preanalytical guidance were provided.
CONCLUSION: The WW-FINGERS biorepository provides a world-first platform for harmonized biomarker discovery across diverse populations in dementia prevention, helping to reduce inequities in research participation, accelerating globally representative strategies.
PMID:43001342 | DOI:10.1002/alz.71949
UK DRI Authors
