Abstract
Neuron. 2026 Sep 2;114(17):3130-3132. doi: 10.1016/j.neuron.2026.07.011.
ABSTRACT
Tau pathology closely tracks neuronal loss in Alzheimer's disease, but how phosphorylated tau becomes lethal has remained unclear. Chen et al. identify a dual-hit mechanism: glucose hypometabolism removes a protective A20-mediated brake on necroptosis while phosphorylated tau scaffolds RIPK1 activation, driving tau-associated neuronal death.1.
PMID:42685677 | DOI:10.1016/j.neuron.2026.07.011
UK DRI Authors
