Dr Owen Dando

Senior Bioinformatician

Application of computational techniques, particularly relating to high-throughput sequencing, to neurodegeneration.

Condition

Alzheimer's disease, Frontotemporal dementia, Motor neuron disease/ALS, Vascular dementia

Topics

Cell biology of neurons & glia, Vascular system

Techniques

Bioinformatics, Genomics, Mass spec-based proteomics, Next generation sequencing, Single cell / nucleus transcriptomics, Software development, Spatial transcriptomics, Statistical modelling

News

Key publications

Nat Commun
Published

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors
Irene Molina-Gonzalez, Rebecca K Holloway, Zoeb Jiwaji, Owen Dando, Sarah A Kent, Katie Emelianova, Amy F Lloyd, Lindsey H Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A Febery, Jeffrey A Johnson, Jill H Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J M Howden, Giles E Hardingham, Veronique E Miron
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.
Nat Commun
Published

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Authors
Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingham
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
Cell Rep
Published

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.

Authors
Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jones
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.