Overexpression of mutant human APP(swe) model

Overview: Species

Mouse

Strain common name

APP23

Full nomenclature

B6.Cg-Tg(Thy1-APP)3Somm/J

Genetic background

C57BL/6J

Description of model, including genes and any mutation(s):

https://www.alzforum.org/research-models/app23

Original publication of model

DOI: 10.1073/pnas.94.24.13287

Breeding scheme

Hemizygous used as homozygous die at young age

Type of model

Alzheimer's disease
Availability: Principal investigator

Stuart Allan

Institution

University of Manchester

Named contact

Katy Walsh

Contact email

katy.walsh@postgrad.manchester.ac.uk

Source of model

In-house

Supplier code

-

MTA Holder and Issuing Organisation:

Available from Jackson
Study details: Sex

Male

Age of model

17-19 months

Diet

Standard chow

Cage enrichment and housing

Group housed in IVCs

Types of outcomes measured

Vascular function (i.e. BBB integrity, CBF)

Details of Outcomes Measured

Arterial function

Strengths of Model

- Animals have both vascular and parenchymal amyloid.
- Cognitive deficits observed and functional changes in arteries.

Limitations of Model

- Deficits not observed till animals relatively old. Current work is assessing earlier changes.

Reference to published procedure

DOI: 10.1073/pnas.2204581119