- Overview
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Species
RatStrain common name
SHRSPFull nomenclature
Spontaneously hypertensive stroke prone ratGenetic background
Wistar-KyotoDescription of model, including genes and any mutation(s):
Bred in Japan in the 1970s by selective breeding to produce hypertensive, then stroke prone-ness and stroke resistant varieties; it is part of a series of inbred strains with metabolic disorders including diabetes, raised cholesterol, etc.
Original publication of model
DOI: 10.1111/j.1747-4949.2011.00659.xBreeding scheme
NormalType of model
Small vessel disease - Availability
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Principal investigator
Joanna Marguerite WardlawInstitution
UK DRI at EdinburghNamed contact
Joanna Marguerite WardlawContact email
joanna.wardlaw@ed.ac.ukSource of model
In-houseMTA Holder and Issuing Organisation:
Obtained from University of Glasgow, BHF Centre, Anna Dominiczak - Study details
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Sex
BothAge of model
Few days oldDuration of Study
24 weeksDiet
Standard chow without salt loadingCage enrichment and housing
Conventional housingTypes of outcomes measured
Omics (i.e transcriptomics, proteomics, metabolomics)Structural measure (i.e. IHC, EM, structural MRI)Details of Outcomes Measured
Structure (histology, IHC, EM), mRNA
Strengths of Model
- Reflective of the messy nature of human small vessel disease
- Identified the gene responsible for the neonatal endothelial cell dysfunction (ATP11B missing)Limitations of Model
- Complex model - becomes hypertensive
- In later life the uncontrolled hypertension clouds the underlying susceptibility to small vessel disease and confused many people in the pastReference to published procedure
DOI: 10.1126/scitranslmed.aam9507
Image
Severe hypertension and cerebral stroke model
Small vessel disease, Risk factor/ co-morbidity (i.e. hypertension, obesity, diabetes)