• Please note all times are in BST

11:00 – Welcome address

11:05 – Ludo Van Den Bosch (VIB-KU Leuven, Belgium)
The role of HDAC6 in axonal degeneration and regeneration

11:45 – Emanuele Buratti (International Centre for Genetic Engineering and Biotechnology, Italy)
Cross-comparison of hnRNP controlled transcripts identifies NOS1AP as a new target in ALS pathology

12:15 – Eva Hedlund (Stockholm University, Sweden)
Decoding motor neuron vulnerability and resilience in ALS

12:45 – Break (15 minutes)

13:00 – Rapid fire talks (to be selected from submitted abstracts)

13:15 - Sebastian Lewandowski (Karolinska Institute, Sweden)
Early perivascular fibroblast activity precedes the onset of ALS neurodegeneration

13:30 – Laura Ranum (University of Florida, USA)
Targeting RAN proteins rescues ALS/FTD in C9orf72 BAC mice

14:00 – Alyssa Coyne (John Hopkins University, School of Medicine, USA)
Nuclear accumulation of CHMP7 initiates NPC injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

14:15 – Kurt De Vos (University of Sheffield, UK)
Loss of TMEM106B increases C9ALS/FTD DPR proteins by disrupting lysosome positioning and autophagy

14:30 – Break (15 minutes)

14:45 – Adrian Isaacs (UK Dementia Research Institute at University College London, UK)
C9orf72 FTD/ALS disease mechanisms

15:15 – Conclusion of the day

• Please note all times are in BST

11:00 – Welcome address

11:05 – Dorothee Dormann (Johannes Gutenberg University and Institute of Molecular Biology Mainz, Germany)
Regulation of ALS/FTD-linked proteins by nuclear import receptors and post-translational modifications

11:45 – Hideyuki Okano (Keio University, Japan)
iPSCs-based drug development for ALS and clinical trial

12:15 – Laura Ferraiuolo (University of Sheffield, UK)
Patient stratification approaches based on drug response using patient-derived cells

12:45 – Break (15 minutes)

13:00 – Rapid fire talks (to be selected from submitted abstracts)

13:15 – Alessandro Rosa (Sapienza University of Rome, Italy)
RNA-binding protein network alteration causes axonal phenotypes in FUS ALS mutant motoneurons

13:30 – Aaron Gitler (Stanford University, USA)
New TDP-43 targets

14:00 – Clotilde Lagier-Tourenne (Massachusetts General Hospital & Harvard Medical School, USA)
Disruption of RNA metabolism in ALS/FTD and emerging therapeutic strategies

14:30 – Break (15 minutes)

14:45 – Rapid fire talks (to be selected from submitted abstracts)

15:00 – Daniel Jutzi (UK Dementia Research Institute at King’s College London)
UK Aberrant FUS-U1 snRNA interactions in FUS-linked ALS

15:15 - Nicol Birsa (UCL Queen Square Institute of Neurology, UK)  Protein translation and LLPS impairments in ALS-FUS motor neurons

15:30 – Conclusion of the day

• Please note all times are in BST

11:00 – Welcome address

11:05 – Séverine Boillée (Paris Brain Institute, France)
Microglia/macrophage contribution to ALS

11:45 – Luc Dupuis (University of Strasbourg, France)
Role of FUS in synaptic gene expression: from the neuromuscular junction to the central nervous system

12:15 – Rickie Patani (University College London & Francis Crick Institute, UK)
Decoding cell type-specific molecular aberrations in ALS using human stem cell models

12:45 – Break (15 minutes)

13:00 – Rapid fire talks (to be selected from submitted abstracts)

13:15 – Karthik Krishnamurthy (Thomas Jefferson University, USA) Aberrant expression of the axon guidance cue netrin-1 by SOD1-ALS astrocytes contributes to motor neuron dysfunction in models of SOD1-ALS

13:30 – Chris Shaw (UK Dementia Research Institute at King’s College London)
Genetic therapies for ALS: Are we there yet?

14:00 – Magdalini Polymenidou (University of Zürich, Switzerland)
Synaptic accumulation of FUS triggers early misregulation of synaptic RNAs in ALS-FUS mice

14:30 – Break (15 minutes)

14:45 – Ilary Allodi (University of Copenhagen, DK)
Locomotor deficits in a mouse model of ALS are paralleled by loss of Engrailed-1 interneurons

15:00 – Alain Prochiantz (College de France, France)
EN1 homeoprotein transcription factor is a direct non-cell autonomous survival factor for spinal cord a-Motoneurons

15:30 – Conclusion of the meeting