UK DRI at KCL: Official Opening
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Let's Tear Down Dementia together!

Over two days, scientists in the UK Dementia Research Insitute at King's College London along with other scientists in the Maurice Wohl Clinical Neuroscience Institute will showcase new and cutting-edge research in the fight to end dementia. Talks will provide insight into the molecular mechanisms of neurogenerative diseases to better understand these diseases and pathways to cure them.

Tear Down Dementia! Celebration

On Monday, the day will close with a celebration of the UK DRI at King's and the Wohl Institute's researchers' commitment to ending dementia. This celebration will include a short talk on the importance of diversity in research along with an interactive session during which attendees will literally “tear down dementia.” This will culminate in the unveiling of a piece of art inspired by the research being conducted by DRI researchers at King’s and other researchers in the Maurice Wohl Institute for Clinical Neuroscience.

About the UK Dementia Research Institute at King's College London

“From bedside to bench to bedside with a cure”

The UK DRI at Kings College London aims to identify the distinct and distinguishing features of different dementias using patient-derived ALS-, FTD- and AD data. This data will then be used to study etiologic mechanisms at the atomic, molecular, cellular and organism levels, to design early-stage diagnostics and to develop therapeutics for effective cure.

Monday 18 February 2019

12:45 Registration

13:15 Welcome, Associate Director of UK Dementia Research Institute at King's College London Professor Chris Shaw

13:20 Official Opening, Executive Dean of Institute of Psychiatry, Psychology & Neuroscience Professor Ian Everall

13:30 Greetings, Director of UK Dementia Research Institute Professor Bart de Stooper

13:35 Vision of the UK DRI, Director of UK Dementia Research Instiute, Operations, Dr Adrian Ivinson

Session 1- RNA Binding Proteins & RNAs in Neurodegeneration

13:45 Professor Chris Shaw, ARPP21 is an ALS Gene: thinking outside the nuclear box

14:10 Priv-Doz, Dr Marc-David Ruepp, FUS-RNA interactions in health and disease

14:35 Dr Jemeen Sreedharan, MRI reveals cerebellar and frontal cortical deficits in the TDP-43(Q331K) knock-in mouse model of ALS-FTD

15:00 Dr Elsa Zacco, Natural RNA-protein interactions for preventing aberrant aggregation: the case of TDP-43

15:15 Break/Tea/Coffee

Session 2- Glia in Neurodegeneration

15:45 Professor Dr Christian Haass, Keynote, TREM2 function and dysfunction in neurodegenerative diseases

16:00 Professor Lawrence Rajendran, TBA

16:15 Professor Marios Politis, PET imaging of neurodegeneration

16:30 Dr Maria Jimenez Sanchez, Astrocyte-secreted chaperones and their role in astrocyte-neuron communication

16:45 Professor Josef Priller, University of Edinburgh, TBA

17:00 Dr Walther Haenseler, University of Zurich, Modelling neurodegenerative diseases with human pluripotent stem cell derived microglia

17:30 Tear Down Dementia! Celebration

Wohl Cafe

Tuesday 19 February 2019

09:00 Registration

Session 3- Post-tranlsational Modifications

09:30 Professor Sir Christopher Dobson, Keynote, The kinetics and mechanisms of protein aggregation

10:00 Professor Annalisa Pastore, Post-translational modifications in neurodegeneraiorn

10:20 Dr Francesco Aprile, University of Cambridge, Targeting Alzheimer's associated amyloid oligomers using antibodies

10:40 Dr Manuel Müller, Chemical synthesis of post-translationally modified proteins

11:00 Break/Tea/Coffee

Session 4- Advanced Imaging in Neurodegeneration

11:30 Dr Sarah Mizielinska, Dysfunctional nucleocytoplasmic transport in FTD/ALS - a direct role for the nuclear pore?

11:50 Dr Caroline Vance, FUS function and dysfunction at the neuromuscular junction

12:15 Dr Alessio Vagnoni, Probing the intracellular dynamics of ageing neurons in Drosophila and beyond

12:40 Dr Kate Sellers, Imaging the nanoscopic organisation and dynamics of synapses in AD

13:00 Lunch & poster session

Session 5- Synapse and disease

14:15 Dr Morgan Sheng, Keynote, Mechanisms of synapse loss in Alzheimer’s disease and tauopathy

14:50 Professor Kei Cho, Synapse weakening: Phathophysiology of Alzheimer’s disease

15:10 Professor Peter Giese, Do deficits in synaptic protein synthesis underlie pathology and memory loss in Alzheimer's disease?

15:30 Professor Juan Burrone, Plasticity of axo-axonic synapses at the axon initial segment

15:45 Professor Chris Shaw, Closing Remarks