Workshop: Neurofilament as a biomarker

Conveners: Henrik Zetterberg (UCL) and Paul Matthews (Imperial)

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LIMITED SPACE register early UKDRI@imperial.ac.uk


MEETING PROGRAMME

Registration and welcome: 9.00 – 9.30

Session I: 9.30 – 12.15

  • The neurobiology of neurofilaments, Jean-Pierre Julien, Laval University, Quebec
  • Clinical observations of NfL and NfH in CSF and serum, Henrik Zetterberg, UK DRI at UCL
  • Methodological considerations for assays for NfL and NfH, Jens Kuhle, University of Basel

Discussion:

• What are functional roles of NfL?
• What have we learned from observations in human disease?
• What is being measured? Can observations in CSF and blood be interpreted in similar ways?

Session II: 1.00 – 3.15

  • Synaptic NfL and clearance of the protein, Ralph Nixon, NYU School of Medicine 
  • Mechanisms of protein clearance from the CNS compartment, Roy Weller, University of Southampton
  • Degradation of intermediate filaments, Pascale Bomont, University of Montpellier
  • Neurofilament dynamics and its relevance to neurological disease, Heather Durham, Montreal Neurological Institute, McGill University

Session III: 3.45 – 6.00

  • Stable isotope studies of protein turnover in the CNS, Nicolas Barthelmy, Washington University School of Medicine, St Louis

Discussion:

• What are the key questions that need to be addressed to understand mechanisms of NfL release and distribution?
• What are the key questions that need to be addressed for accurate clinical interpretations, particularly in the context of chronic neurodegenerative diseases?
• What are the experiments that could be done to answer these questions? For example, what models for understanding mechanisms and interpretation of NfL could be made?

Drinks and Networking Reception: 6.00 – 7.00

Meeting Close: 7pm

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