LIMITED SPACE – register early UKDRI@imperial.ac.uk
Registration and welcome: 9.00 – 9.30
Session I: 9.30 – 12.15
- The neurobiology of neurofilaments, Jean-Pierre Julien, Laval University, Quebec
- Clinical observations of NfL and NfH in CSF and serum, Henrik Zetterberg, UK DRI at UCL
- Methodological considerations for assays for NfL and NfH, Jens Kuhle, University of Basel
• What are functional roles of NfL?
• What have we learned from observations in human disease?
• What is being measured? Can observations in CSF and blood be interpreted in similar ways?
Session II: 1.00 – 3.15
- Synaptic NfL and clearance of the protein, Ralph Nixon, NYU School of Medicine
- Mechanisms of protein clearance from the CNS compartment, Roy Weller, University of Southampton
- Degradation of intermediate filaments, Pascale Bomont, University of Montpellier
- Neurofilament dynamics and its relevance to neurological disease, Heather Durham, Montreal Neurological Institute, McGill University
Session III: 3.45 – 6.00
- Stable isotope studies of protein turnover in the CNS, Nicolas Barthelmy, Washington University School of Medicine, St Louis
• What are the key questions that need to be addressed to understand mechanisms of NfL release and distribution?
• What are the key questions that need to be addressed for accurate clinical interpretations, particularly in the context of chronic neurodegenerative diseases?
• What are the experiments that could be done to answer these questions? For example, what models for understanding mechanisms and interpretation of NfL could be made?
Drinks and Networking Reception: 6.00 – 7.00
Meeting Close: 7pm