Claire Durrant

Dr Claire Durrant

Emerging Leader

Using organotypic cultures and human tissue to explore mechanisms of synapse loss in Alzheimer’s disease

Biography

Dr Claire Durrant is a Race Against Dementia (RAD) Dyson Fellow; supported by Sir Jackie Stewart’s pioneering dementia research charity and funded by the James Dyson Foundation. Prior to starting her RAD fellowship in September 2019, Dr Durrant completed her PhD and postdoctoral studies in the lab of Prof Michael Coleman at the University of Cambridge. She then moved to the University of Edinburgh in collaboration with her academic sponsor Prof Tara Spires-Jones, before becoming a UK DRI Emerging Leader in 2021. Dr Durrant specialises in using organotypic cultures and post-mortem human tissue to explore mechanisms of synapse loss in Alzheimer’s disease.

News

Key publications

The European journal of neuroscience
Published

Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

Authors
Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo, Calum Bonthron, Soraya Meftah, Caleb Stoddart-Campbelton, Arisa Tamura, Jamie Rose, Colin Smith, Claire Durrant, Tara L Spires-Jones
Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease
Nature Reviews Neurology
Published

Synaptic degeneration in Alzheimer disease

Authors
Makis Tzioras, Robert I. McGeachan, Claire S. Durrant, Tara L Spires-Jones
Synaptic degeneration in Alzheimer disease

Durrant Lab

Explore the work of the Durrant Lab, using organotypic cultures and human tissue to explore mechanisms of synapse loss in Alzheimer’s disease

Durrant Lab
Piece of human brain cortex stained amyloid beta protein