Amanda Heslegrave

Dr Amanda Heslegrave

Principal Research Fellow

Co-leading the UK DRI Biomarker Factory platform based at UK DRI at UCL

Biography

Dr. Amanda Heslegrave is Principal Research Fellow at the UK DRI at UCL, where she co-leads the fluid biomarker (Zetterberg) laboratory and the UK DRI Biomarker Factory. After completing her BSc from Birkbeck, University of London (2000) and PhD from UCL (2005), she transitioned to biomarker research in 2012 with Prof Henrik Zetterberg at UCL. Her research focuses on fluid biomarkers in CSF and blood, utilising immunoassay and proteomic methods to study neurodegenerative diseases. 

News

Key publications

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Authors
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K W Cheng, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Siu Ki Leung, Fanny C Ip, Jacqueline K Y Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Psychological medicine
Published
Subjective estimation of cognitive function in mild cognitive impairment: relationship with neurodegenerative and non-degenerative factors
Authors
Calum A Hamilton, Peter Gallagher, Paul C Donaghy, Joanna Ciafone, Michael Firbank, Gemma Greenfinch, Amanda Heslegrave, Henrik Zetterberg, John-Paul Taylor, Louise M Allan, John T O'Brien, Alan J Thomas
Subjective estimation of cognitive function in mild cognitive impairment: relationship with neurodegenerative and non-degenerative factors
Brain communications
Published
Inflammation PET and plasma neurofilament light predict survival in people with progressive supranuclear palsy
Authors
Noah L Shapiro, Peter Simon Jones, Elijah Mak, Kamen A Tsvetanov, Julia Goddard, Davi S Vontobel, Robert Durcan, Leonidas Chouliaras, Tim Fryer, Young T Hong, Franklin Aigbirhio, Amanda Heslegrave, Nicolai Franzmeier, Matthias Brendel, Henrik Zetterberg, John T O'Brien, James B Rowe, Maura Malpetti
Inflammation PET and plasma neurofilament light predict survival in people with progressive supranuclear palsy
Scientific reports
Published
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Authors
Felix Klawitter, Johanna Hackenberg, Lena Danckert, Astrid Bertsche, Axel Petzold, Heidi A B Smith, Eugene Wesley Ely, Christian Spang, Rika Bajorat, Dagmar-Christiane Fischer, Gerd Klinkmann, Anne Körmann-Günther, Robert Fleischmann, Amanda Heslegrave, Henrik Zetterberg, Hessel Peters-Sengers, Johannes Ehler, Critical Care Consultant
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study

The Biomarker Factory

Dr Amanda Heslegrave co-leads the UK DRI Biomarker Factory, transforming the early detection, diagnosis and monitoring of dementia, by facilitating the development of fluid biomarkers for research and the clinic

UK DRI Biomarker Factory
Scientists posing in the lab in white coats