Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Brain Commun

Published Aug 06, 2021

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Authors

Jasmine Harley, Cathleen Hagemann, Andrea Serio, Rickie Patani

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Dev Neurobiol

Published Jul 31, 2021

Understanding microglial diversity and implications for neuronal function in health and disease.

Authors

Sebastiaan De Schepper, Gerard Crowley, Soyon Hong

Understanding microglial diversity and implications for neuronal function in health and disease.

Am J Pathol

Published Jul 27, 2021

Interplay between Brain Pericytes and Endothelial Cells in Dementia.

Authors

Tessa V Procter, Anna Williams, Axel Montagne

Interplay between Brain Pericytes and Endothelial Cells in Dementia.

Nat Commun

Published Jul 23, 2021

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Authors

Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Nat Commun

Published Jul 23, 2021

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Authors

Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Nucleic Acids Res

Published Jul 21, 2021

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Authors

Stefan Reber, Daniel Jutzi, Helen Lindsay, Anny Devoy, Jonas Mechtersheimer, Brunno Rocha Levone, Michal Domanski, Eva Bentmann, Dorothee Dormann, Oliver Mühlemann, Silvia M L Barabino, Marc-David Ruepp

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Nucleic Acids Res

Published Jul 21, 2021

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Authors

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Sci Adv

Published Jul 08, 2021

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors

Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Sci Adv

Published Jul 08, 2021

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

J Neurol Neurosurg Psychiatry

Published Jul 03, 2021

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors

Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

J Neurol Neurosurg Psychiatry

Published Jul 03, 2021

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Physiol Rev

Published Jul 01, 2021

Do hippocampal pyramidal cells respond to nonspatial stimuli?

Authors

John O'Keefe, Julija Krupic

Do hippocampal pyramidal cells respond to nonspatial stimuli?

Physiol Rev

Published Jul 01, 2021