Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Nat Methods

Published Jan 13, 2020

Probabilistic cell typing enables fine mapping of closely related cell types in situ.

Authors

Xiaoyan Qian, Kenneth D Harris, Thomas Hauling, Dimitris Nicoloutsopoulos, Ana B Muñoz-Manchado, Nathan Skene, Jens Hjerling-Leffler, Mats Nilsson

Probabilistic cell typing enables fine mapping of closely related cell types in situ.

Lancet Neurol

Published Jan 09, 2020

Neuromyelitis optica in patients with increased interferon alpha concentrations.

Authors

Jac Williams, Sarah McGlasson, Sarosh Irani, Darragh Duffy, Yanick Crow, David Hunt

Neuromyelitis optica in patients with increased interferon alpha concentrations.

Lancet Neurol

Published Jan 01, 2020

Neuromyelitis optica in patients with increased interferon alpha concentrations.

Authors

Jac Williams, Sarah McGlasson, Sarosh Irani, Darragh Duffy, Yanick Crow, David Hunt,

Neuromyelitis optica in patients with increased interferon alpha concentrations.

Brain Commun

Published Jan 01, 2020

OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory.

Authors

Ryan J Bevan, Pete A Williams, Caroline T Waters, Rebecca Thirgood, Amanda Mui, Sharon Seto, Mark Good, James E Morgan, Marcela Votruba, Irina Erchova

OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory.

Brain Commun

Published Jan 01, 2020

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

Authors

John B Sanderson, Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini, Aurelia Hays Watson, Laura De Boni, Valentina N Lagomarsino, Tracy L Young-Pearse, Xinyue Liu, Thomas C Pochapsky, Bradley T Hyman, Dennis W Dickson, David Klenerman, Dennis J Selkoe, Tim Bartels

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

Front Hum Neurosci

Published Jan 01, 2020

Brain Activity Reveals Multiple Motor-Learning Mechanisms in a Real-World Task.

Authors

Shlomi Haar, A Aldo Faisal

Brain Activity Reveals Multiple Motor-Learning Mechanisms in a Real-World Task.

Brain Commun

Published Jan 01, 2020

A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE.

Authors

Andre Altmann, Marzia A Scelsi, Maryam Shoai, Eric de Silva, Leon M Aksman, David M Cash, John Hardy, Jonathan M Schott

A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE.

Nat Neurosci

Published Dec 31, 2019

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Authors

Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Acta Neuropathol Commun

Published Dec 20, 2019

Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.

Authors

Raphael Hesse, Maica Llavero Hurtado, Rosemary J Jackson, Samantha L Eaton, Abigail G Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M Henstridge, Douglas Lamont, Thomas M Wishart, Tara L Spires-Jones

Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.

Nat Neurosci

Published Dec 17, 2019

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.

Authors

Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, Nancy C Hernandez Villegas, Maoping Tang, Paula V M Cauhy, Benjamin A Lassus, Shuo Chen, Stephanie L Fowler, Helen Y Figueroa, Edward D Huey, Gail V W Johnson, Michele Vendruscolo, Karen E Duff

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.

Glia

Published Dec 16, 2019

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.

Authors

Chen Zhao, Anna-Claire Devlin, Amit K Chouhan, Bhuvaneish T Selvaraj, Maria Stavrou, Karen Burr, Veronica Brivio, Xin He, Arpan R Mehta, David Story, Christopher E Shaw, Owen Dando, Giles E Hardingham, Gareth B Miles, Siddharthan Chandran

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.

Acta Neuropathol

Published Dec 12, 2019

Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

Authors

Lauren M Gittings, Steven Boeynaems, Daniel Lightwood, Alison Clargo, Sarfaraj Topia, Lisa Nakayama, Claire Troakes, David M A Mann, Aaron D Gitler, Tammaryn Lashley, Adrian M Isaacs

Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

Nat Commun

Published Dec 12, 2019

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.

Authors

Thomas Knöpfel, Yann Sweeney, Carola I Radulescu, Nawal Zabouri, Nazanin Doostdar, Claudia Clopath, Samuel J Barnes

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.

Cell Reports

Published Dec 10, 2019

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease

Authors

Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease

Cell Rep

Published Dec 10, 2019

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.

Authors

Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jones

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.

Neurology

Published Dec 03, 2019

Cognition at age 70: Life course predictors and associations with brain pathologies.

Authors

Kirsty Lu, Jennifer M Nicholas, Jessica D Collins, Sarah-Naomi James, Thomas D Parker, Christopher A Lane, Ashvini Keshavan, Sarah E Keuss, Sarah M Buchanan, Heidi Murray-Smith, David M Cash, Carole H Sudre, Ian B Malone, William Coath, Andrew Wong, Susie M D Henley, Sebastian J Crutch, Nick C Fox, Marcus Richards, Jonathan M Schott

Cognition at age 70: Life course predictors and associations with brain pathologies.

Science

Published Nov 29, 2019

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Authors

Alexi Nott, Inge R Holtman, Nicole G Coufal, Johannes C M Schlachetzki, Miao Yu, Rong Hu, Claudia Z Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, Martina P Pasillas, Carolyn O'Connor, Christian K Nickl, Simon T Schafer, Zeyang Shen, Robert A Rissman, James B Brewer, David Gosselin, David D Gonda, Michael L Levy, Michael G Rosenfeld, Graham McVicker, Fred H Gage, Bing Ren, Christopher K Glass

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Science

Published Nov 29, 2019

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Authors

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.