Abstract
Trends Neurosci. 2025 Feb 10:S0166-2236(25)00018-9. doi: 10.1016/j.tins.2025.01.004. Online ahead of print.
ABSTRACT
Tau phosphorylation plays an essential role in regulating tau's microtubule-stabilizing function, but its hyperphosphorylation drives tauopathies such as Alzheimer's disease (AD). In a recent study, Kim and colleagues decipher that tyrosine kinase 2 (TYK2) phosphorylates tau at tyrosine 29, promoting its stabilization and aggregation by interfering with autophagic clearance, providing novel insights into tau pathology and potential therapeutic strategies.
PMID:39934052 | DOI:10.1016/j.tins.2025.01.004