Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy.

Authors

Nazanin Makkinejad, Maria Clara Zanon Zotin, Hilde van den Brink, Corinne A Auger, Kali A Vom Eigen, Juan Eugenio Iglesias, Steven M Greenberg, Valentina Perosa, Susanne J van Veluw

Abstract

White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it remains largely unexplored whether the different WMH distribution patterns associated with CAA (posterior confluent and subcortical multispot) reflect alternative pathophysiological mechanisms.

PMID:39526350 | DOI:10.1161/JAHA.124.035744

UK DRI Authors

Dr Hilde van den Brink

Postdoctoral Researcher

Identifying the mechanisms that drive brain haemorrhages in CAA, with a broader interest in shared disease mechanisms across cerebral small vessel diseases.

Dr Hilde van den Brink