Bart De Strooper

Prof Bart De Strooper

Group Leader

Investigating the cellular reaction to amyloid beta and tau protein in Alzheimer's disease

Condition

Alzheimer's disease

Biography

Prof Bart De Strooper is a world-renowned Alzheimer's disease researcher, formerly based at the KU Leuven in Belgium, and was the founding Institute Director for the UK DRI (2017- 2023). 

He was Director at the Vlaams Instituut voor Biotechnologie and led a neuroscience department of over 250 researchers. He was elected to the Academy of Medical Sciences Fellowship in 2020, and has received several awards including the Potamkin prize, the Metlife Foundation Award for Medical Research, Alois Alzheimer’s prize, the highly prestigious Brain Prize 2018 and Commander in the Order of Leopold I. 

Prof De Strooper's research group at the UK DRI at UCL interrogates the fundamental mechanisms underlying Alzheimer’s and Parkinson’s disease.

News

Key publications

Science
Published
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.
Authors
Heather C Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M Ranaivoson, Davide Comoletti, Jeffrey N Savas, Han Remaut, Detlef Balschun, Keimpe D Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.
Proc Natl Acad Sci U S A
Published
PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.
Authors
Marco Spinazzi, Enrico Radaelli, Katrien Horré, Amaia M Arranz, Natalia V Gounko, Patrizia Agostinis, Teresa Mendes Maia, Francis Impens, Vanessa Alexandra Morais, Guillermo Lopez-Lluch, Lutgarde Serneels, Placido Navas, Bart De Strooper
PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.
Brain
Published
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Authors
Frances K Wiseman, Laura J Pulford, Chris Barkus, Fan Liao, Erik Portelius, Robin Webb, Lucia Chávez-Gutiérrez, Karen Cleverley, Sue Noy, Olivia Sheppard, Toby Collins, Caroline Powell, Claire J Sarell, Matthew Rickman, Xun Choong, Justin L Tosh, Carlos Siganporia, Heather T Whittaker, Floy Stewart, Maria Szaruga, , Michael P Murphy, Kaj Blennow, Bart de Strooper, Henrik Zetterberg, David Bannerman, David M Holtzman, Victor L J Tybulewicz, Elizabeth M C Fisher,
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

De Strooper Lab

Explore the work of the De Strooper Lab Investigating the cellular reaction to amyloid beta and tau protein in Alzheimer's disease

 
De Strooper Lab