Dr Emmanouil Metzakopian

News

Jan 18, 2024 - Research

New insight into the effects of Parkinson’s on different cell types in the brain

A study led by Dr Emmanouil Metzakopian and Prof Matthew G. Holt has uncovered fresh...

Learn more New insight into the effects of Parkinson’s on different cell types in the brain

Sep 14, 2021 - Research

Researchers identify neuroprotective protein in Parkinson’s disease

In a new study published today (14 Sept) in Cell Reports, researchers have shown that...

Learn more Researchers identify neuroprotective protein in Parkinson’s disease

Key publications

Neuron

Published Apr 22, 2025

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition

Authors

Sung Min Son, Farah H Siddiqi, Ana Lopez, Rizwan Ansari, Sylwia D Tyrkalska, So Jung Park, Tilo Kunath, Emmanouil Metzakopian, Angeleen Fleming, David C Rubinsztein

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition

EMBO J

Published Jul 17, 2023

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Authors

Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Cell Rep

Published May 03, 2022

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors

Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Nat Commun

Published Jan 08, 2019

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

Authors

Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T Durant, Yaron Galanty, Petra Beli, David J Adams, Allan Bradley, Emmanouil Metzakopian, Josep V Forment, Stephen P Jackson

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.