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Marc Aurel Busche profile picture

Dr Marc Aurel Busche

(MD, PhD)

Group Leader

Understanding and repairing pathological neural circuits in Alzheimer's disease

Techniques

Advanced microscopy & imaging, Electrophysiology, Experimental medicine, Human brain imaging, Mouse behaviour, Mouse in vivo imaging, Optogenetics, Stem cells / iPSCs

Biography

Dr. Marc Aurel Busche is a psychiatrist and neuroscientist at the UK Dementia Research Institute at UCL. 

His major focus is to understand the cellular and circuit mechanisms that underlie the initiation and progression of Alzheimer’s Disease (AD) and related disorders so that, through this understanding, more effective therapies can be developed. He also provides patient care as an honorary consultant psychiatrist in the cognitive disorders clinic at the Queen Square National Hospital for Neurology and Neurosurgery. 

Dr. Busche attended medical school at the Ludwig Maximilians University of Munich, and completed his clinical training in psychiatry and psychotherapy at the University Hospital of the Technical University of Munich. He performed his graduate work with Arthur Konnerth at the Technical University of Munich, carried out research as a Tandem Group Leader at the Munich Cluster for Systems Neurology and also performed an EMBO Fellowship at Massachusetts General Hospital and Harvard Medical School with Bradley Hyman. 

He is the recipient of several awards and fellowships including a UKRI Future Leaders Fellowship.

News

Key publications

Cell
Published
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
Authors
Samuel S Harris, Robert Ellingford, Jana Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M Rajani, David Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins, Zhanyun Fan, Suraya A Bond, Fred Wolf, David Dupret, Raymond J Dolan, Arthur Konnerth, Andreas Neef, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
PLoS Biol
Published
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Authors
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Nat Neurosci
Published
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Authors
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Ben Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.

Busche Lab

Explore the work of the Busche Lab focused on understanding and repairing pathological neural circuits in Alzheimer's disease.

Plaques and tangles in cortex in vitro