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Valentina Escott-Price

Prof Valentina Escott-Price

((she/her))

Group Leader

Using Big Data, machine learning and AI to accelerate discoveries into dementia

Techniques

Bioinformatics, Epigenomics, Genomics, Next generation sequencing, Software development, Statistical modelling

Biography

Valentina's academic career began with a strong foundation in mathematics from St. Petersburg University in Russia, followed by a PhD in Statistics from Cardiff University. Since then, her innovative approaches in statistical methodology have significantly advanced our understanding of Alzheimer's disease. 

As a main member of the international Alzheimer’s disease consortia (International Genomics of Alzheimer’s Project consortium (IGAP) and European Alzheimer's Disease DNA BioBank (EADB)), she played a crucial role in identifying new genetic loci linked to Alzheimer's, adding to the knowledge base necessary for developing better diagnostic tools and treatments. 

Valentina’s extensive multidisciplinary expertise spans genetic data analysis in dementias including Parkinson’s disease, Vascular dementia, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, and dementia-related phenotypes. 

Her work focuses on accurately identifying individuals at high risk of disease, utilising polygenic risk scores, biomarkers and environmental risk factors. Her primary interest, however, remains statistical methodology, and she continually strives to optimise approaches and explore novel methodologies for the analysis of large complex datasets. 

Her current objectives include leveraging artificial intelligence (AI) and machine learning methods to enhance disease risk prediction and patient stratification in large population-level data, as well as employing cutting-edge federated and swarm learning approaches for remote and secure data analyses.

News

Key publications

Science advances
Published
Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
Authors
Mohammad Shafieinouri, Samantha Hong, Paul Suhwan Lee, Spencer M Grant, Marzieh Khani, Anant Dadu, Artur F Schumacher Schuh, Mary B Makarious, Rodrigo Sandon, Emily Simmonds, Hirotaka Iwaki, Gracelyn Hill, Cornelis Blauwendraat, Valentina Escott-Price, Yue A Qi, Alastair J Noyce, Armando Reyes-Palomares, Hampton L Leonard, Malu Tansey, Faraz Faghri, Andrew B Singleton, Mike A Nalls, Kristin S Levine, Sara Bandres-Ciga
Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
Stem cell reports
Published
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Nature genetics
Published
Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
Authors
Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Jigyasha Timsina, Itziar de Rojas, María Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia L Satizabal, Bernard Fongang, Qiong Yang, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina-Porcel, Emrah Düzel, Timo Grimmer, Jens Wiltfang, Stefanie Heilmann-Heimbach, Susanne Moebus, Thomas Tegos, Nikolaos Scarmeas, Oriol Dols-Icardo, Fermin Moreno, Jordi Pérez-Tur, María J Bullido, Pau Pastor, Raquel Sánchez-Valle, Victoria Álvarez, Han Cao, Nancy Y Ip, Amy K Y Fu, Fanny C F Ip, Natividad Olivar, Carolina Muchnik, Carolina Cuesta, Lorenzo Campanelli, Patricia Solis, Daniel Gustavo Politis, Silvia Kochen, Luis Ignacio Brusco, Mercè Boada, Pablo García-González, Raquel Puerta, Pablo Mir, Luis M Real, Gerard Piñol-Ripoll, Jose María García-Alberca, Jose Luís Royo, Eloy Rodriguez-Rodriguez, Hilkka Soininen, Sami Heikkinen, Alexandre de Mendonça, Shima Mehrabian, Latchezar Traykov, Jakub Hort, Martin Vyhnalek, Katrine Laura Rasmussen, Jesper Qvist Thomassen, Yolande A L Pijnenburg, Henne Holstege, John C van Swieten, Harro Seelaar, Jurgen A H R Claassen, Willemijn J Jansen, Inez Ramakers, Frans Verhey, Aad van der Lugt, Philip Scheltens, Jenny Ortega-Rojas, Ana Gabriela Concha Mera, Maria F Mahecha, Rodrigo Pardo, Gonzalo Arboleda, Shahram Bahrami, Vera Fominykh, Geir Selbæk, Caroline Graff, Goran Papenberg, Vilmantas Giedraitis, Anne Boland, Jean-François Deleuze, Luiz Armando de Marco, Edgar Nunes de Moraes, Bernardo de Mattos Viana, Marco Túlio Gualberto Cintra, Teresa Juarez-Cedillo, Anthony J Griswold, Tatiana Forund, Jonathan Haines, Lindsay Farrer, Anita DeStefano, Ellen Wijsman, Richard Mayeux, Margaret Pericak-Vance, Brian Kunkle, Alison Goate, Gerard D Schellenberg, Badri Vardarajan, Li-San Wang, Yuk Yee Leung, Clifton L Dalgard, Gael Nicolas, David Wallon, Carole Dufouil, Florence Pasquier, Olivier Hanon, Stéphanie Debette, Edna Grünblatt, Julius Popp, Bárbara Angel, Sergio Gloger, Maria Victoria Chacon, Rafael Aranguiz, Paulina Orellana, Andrea Slachevsky, Christian Gonzalez-Billault, Cecilia Albala, Patricio Fuentes, Perminder Sachdev, Karen A Mather, Richard L Hauger, Victoria Merritt, Matthew Panizzon, Rui Zhang, J Michael Gaziano, Roberta Ghidoni, Daniela Galimberti, Beatrice Arosio, Patrizia Mecocci, Vincenzo Solfrizzi, Lucilla Parnetti, Alessio Squassina, Lucio Tremolizzo, Barbara Borroni, Benedetta Nacmias, Paolo Caffarra, Davide Seripa, Innocenzo Rainero, Antonio Daniele, Fabrizio Piras, EADB, Hampton L Leonard, Jenifer S Yokoyama, Mike A Nalls, Akinori Miyashita, Norikazu Hara, Kouichi Ozaki, Shumpei Niida, Julie Williams, Carlo Masullo, Philippe Amouyel, Pierre-Marie Preux, Pascal Mbelesso, Bébène Bandzouzi, Andy Saykin, Frank Jessen, Patrick G Kehoe, Cornelia Van Duijn, Nesrine Ben Salem, Ruth Frikke-Schmidt, Lotfi Cherni, Michael D Greicius, Magda Tsolaki, Pascual Sánchez-Juan, Marco Aurélio Romano Silva, Tenielle Porter, Simon M Laws, Kristel Sleegers, Martin Ingelsson, Jean-François Dartigues, Sudha Seshadri, Giacomina Rossi, Laura Morelli, Mikko Hiltunen, Rebecca Sims, Wiesje van der Flier, Ole A Andreassen, Humberto Arboleda, Carlos Cruchaga, Valentina Escott-Price, Agustín Ruiz, Kun Ho Lee, Takeshi Ikeuchi, Alfredo Ramirez, Jungsoo Gim, Mark Logue, Jean-Charles Lambert
Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Escott-Price Lab

Explore the work of the Escott-Price Lab focused on using Big Data to accelerate discoveries into dementia.

A graph showing disease risk