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Prof Valentina Escott-Price

(She/Her)

Group Leader

Using Big Data, machine learning and AI to accelerate discoveries into dementia

Techniques

Genomics, Bioinformatics, Epigenomics, Next generation sequencing, Software development, Statistical modelling

Biography

Valentina's academic career began with a strong foundation in mathematics from St. Petersburg University in Russia, followed by a PhD in Statistics from Cardiff University. Since then, her innovative approaches in statistical methodology have significantly advanced our understanding of Alzheimer's disease. 


As a main member of the international Alzheimer’s disease consortia (International Genomics of Alzheimer’s Project consortium (IGAP) and European Alzheimer's Disease DNA BioBank (EADB)), she played a crucial role in identifying new genetic loci linked to Alzheimer's, adding to the knowledge base necessary for developing better diagnostic tools and treatments. 


Valentina’s extensive multidisciplinary expertise spans genetic data analysis in dementias including Parkinson’s disease, Vascular dementia, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, and dementia-related phenotypes. 


Her work focuses on accurately identifying individuals at high risk of disease, utilising polygenic risk scores, biomarkers and environmental risk factors. Her primary interest, however, remains statistical methodology, and she continually strives to optimise approaches and explore novel methodologies for the analysis of large complex datasets. 


Her current objectives include leveraging artificial intelligence (AI) and machine learning methods to enhance disease risk prediction and patient stratification in large population-level data, as well as employing cutting-edge federated and swarm learning approaches for remote and secure data analyses.

Honours & awards

Women in Neuroscience UK 2025 Award: Leadership in Interdisciplinary Research

News

Key publications

Science advances
Published

Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale

Authors
Mohammad Shafieinouri, Samantha Hong, Paul Suhwan Lee, Spencer M Grant, Marzieh Khani, Anant Dadu, Artur F Schumacher Schuh, Mary B Makarious, Rodrigo Sandon, Emily Simmonds, Hirotaka Iwaki, Gracelyn Hill, Cornelis Blauwendraat, Valentina Escott-Price, Yue A Qi, Alastair J Noyce, Armando Reyes-Palomares, Hampton L Leonard, Malu Tansey, Faraz Faghri, Andrew B Singleton, Mike A Nalls, Kristin S Levine, Sara Bandres-Ciga
Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
Stem cell reports
Published

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource

Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource

Escott-Price Lab

Explore the work of the Escott-Price Lab focused on using Big Data to accelerate discoveries into dementia.

A graph showing disease risk