In a new study led by Prof Giampetro Schiavo and Dr James Sleigh (UK DRI at UCL), researchers have developed a new treatment strategy to combat an inherited neuromuscular condition known as Charcot-Marie-Tooth disease. The study is published in the journal JCI Insight.
Charcot-Marie-Tooth disease (CMT) is an inherited nervous system disease that affects 1 in about every 2,500 people, making it one of the most common conditions to affect nerves and muscles. People with CMT have mobility issues and difficulties with sensation because two different types of nerve cell known as motor neurons and sensory neurons, malfunction and deteriorate. It is unknown why these nerve cells are affected in CMT, which has made it difficult to develop treatments for the disease.