John Hardy

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts
Authors
Stacey L Piotrowski, Mary Alice Allnutt, Kory Johnson, Toshiko Tanaka, Luigi Ferrucci, Huw Morris, John Hardy, PROSPECT Consortium, Mina Ryten, United Kingdom Brain Expression Consortium (UKBEC), Giancarlo Logroscino, Juan Troncoso, Thomas G Beach, Geidy E Serrano, Carlos Cruchaga, Dennis W Dickson, Owen A Ross, Adriano Chiò, International LBD Genomics Consortium, International ALS Genomics Consortium, Henry Houlden, American Genome Center, Clifton L Dalgard, Jinhui Ding, J Raphael Gibbs, Bryan J Traynor, Sonja W Scholz, Steven Jacobson
Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts
Frontiers in neuroscience
Published
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Authors
Claudio Villegas-Llerena, Solange R Paredes-Moscosso, María Luisa Guevara-Fujita, Daisy Obispo, Nilton Custodio, Rosa Montesinos, José F Parodi, Oscar Flores-Flores, John Hardy, Ricardo Fujita
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Authors
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Maryam Shoai, Joyce R Chong, Andrew L T Chan, Christopher Chen, Linda C W Lam, Vincent C T Mok, Timothy C Y Kwok, Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative, Yu Chen, Fanny C F Ip, Kin Y Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K Y Fu, Nancy Y Ip
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab