John Hardy

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Frontiers in neuroscience
Published
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Authors
Claudio Villegas-Llerena, Solange R Paredes-Moscosso, María Luisa Guevara-Fujita, Daisy Obispo, Nilton Custodio, Rosa Montesinos, José F Parodi, Oscar Flores-Flores, John Hardy, Ricardo Fujita
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Authors
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Maryam Shoai, Joyce R Chong, Andrew L T Chan, Christopher Chen, Linda C W Lam, Vincent C T Mok, Timothy C Y Kwok, Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative, Yu Chen, Fanny C F Ip, Kin Y Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K Y Fu, Nancy Y Ip
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Authors
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K W Cheng, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Siu Ki Leung, Fanny C Ip, Jacqueline K Y Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Nature biomedical engineering
Published
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue

Hardy Lab

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Hardy Lab