Siddharthan Chandran

Prof Siddharthan Chandran

Director & CEO

Dissecting a genetic cause of ALS and FTD and identifying ways to help protect neurons

Condition

Motor neuron disease/ALS, Frontotemporal dementia

Biography

Professor Siddharthan Chandran is Director of the UK Dementia Research Institute, and an internationally leading expert in neurodegenerative diseases. Prof Chandran is a practising neurologist and scientist working at the forefront of the emerging discipline of Regenerative Neurology, renowned for his work in motor neuron disease (MND) and MS that combines laboratory and clinical research with a particular focus on human / patient stem cells for his discovery science research. Alongside his UK DRI research, Prof Chandran is Director of the Euan MacDonald Centre for Motor Neuron Disease Research and the Anne Rowling Regenerative Neurology Clinic at the University of Edinburgh. He is also a Fellow of the Royal Society of Edinburgh and the Academy of Medical Sciences.

News

Key publications

Science (New York, N.Y.)
Published
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Authors
Donia Arafa, Julia van de Korput, Philipp N Braaker, Kieran P Higgins, Niels R C Meijns, Katy L H Marshall-Phelps, Julia Meng, Daniel Soong, Eleonora Scalia, Kyle Lathem, Marcus Keatinge, Claire Richmond, Anna Klingseisen, Marja Main, Sarah A Neely, David W Hampton, Greg J Duncan, Geert J Schenk, Marie Louise Groot, Siddharthan Chandran, Ben Emery, Antonio Luchicchi, Maarten H P Kole, Anna C Williams, David A Lyons
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
BMJ open
Published
Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia
Authors
Johnny Tam, Christine Weaver, Amarachi Ihenacho, Judith Newton, Bruce Virgo, Steven Barrett, Jonathan Neale, David Perry, Alice Smith, Siddharthan Chandran, Oliver Watts, Suvankar Pal, DASH Consortium
Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia
Molecular medicine (Cambridge, Mass.)
Published
Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
Authors
Andrea Salzinger, Esra Özkan, Vidya Ramesh, Jyoti Nanda, Karen Burr, David Story, Nhan T Pham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
Neuron
Published
The brain neurovascular epigenome and its association with dementia
Authors
Kevin Chris Ziegler, Aydan Askarova, Charbel Gergian, Reuben M Yaa, Janna D van Dalen, Janis Lisa Transfeld, Filippo Zoppi, Jia Du, Daniel Clode, Fatemeh Rahbar, Rebecca E Graham, Muralidharan Sargurupremraj, Stéphanie Debette, David D Gonda, Michael L Levy, Siddharthan Chandran, Sven Falk, Marisa Karow, Paul M Matthews, Nicole G Coufal, Alexi Nott
The brain neurovascular epigenome and its association with dementia

Chandran Lab

Explore the work of the Chandran Lab, Dissecting a genetic cause of ALS and FTD and identifying ways to help protect neurons.

 
Chandran Lab
Human stem cell-derived myelinating oligodendrocyte can be seen with many myelinating processes wrapped around unstained neurons