Profile picture of David Hunt

Prof David Hunt

Group Leader

Investigating how innate immune activation causes damage to the microvasculature of the brain

Biography

Prof David Hunt is a Wellcome Trust Senior Clinical Fellow and Consultant Neurologist based in Edinburgh University who leads clinics and research in the field of brain inflammation. He trained in medicine at Cambridge, London and Basel. His PhD research at Cambridge University was in the field of developmental neuroscience and neuroinflammation. In 2009 he moved to Edinburgh where he completed his neurological training and established a Wellcome Trust-funded laboratory to study the molecular basis of neuroinflammatory diseases. David’s research programme at the UK DRI aim to find ways to target inflammation to stop neurodegeneration, with particular focus on the interplay between interferon, nucleases and microvascular brain disease. This research programme links up clinics, discovery science and clinical trials.

News

Key publications

Multiple sclerosis (Houndmills, Basingstoke, England)
Published
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Movement disorders : official journal of the Movement Disorder Society
Published
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Authors
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha-Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne-Claire Richard, Olivier Quenez, Camilo Toro, Steven J Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M Riboldi
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Nat Med
Published
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.
Authors
Martina Patone, Lahiru Handunnetthi, Defne Saatci, Jiafeng Pan, Srinivasa Vittal Katikireddi, Saif Razvi, David Hunt, Xue W Mei, Sharon Dixon, Francesco Zaccardi, Kamlesh Khunti, Peter Watkinson, Carol A C Coupland, James Doidge, David A Harrison, Rommel Ravanan, Aziz Sheikh, Chris Robertson, Julia Hippisley-Cox
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Hunt Lab

Explore the work of the Hunt Lab, Investigating how innate immune activation causes damage to the microvasculature of the brain

Hunt Lab
Small blood vessels in mice