Jernej Ule profile

Prof Jernej Ule

Centre Director

Deciphering the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia

Condition

Alzheimer's disease, Motor neuron disease/ALS, Frontotemporal dementia

Topics

Ageing, Cell biology of neurons & glia, Molecular mechanisms, Sleep & Circadian rhythms, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Advanced spectroscopy, Bioinformatics, Biophysical techniques, CRISPR, Epigenomics, Flow cytometry, Genomics, Mass spec-based proteomics, Next generation sequencing, Single cell / nucleus transcriptomics, Software development, Spatial transcriptomics, Stem cells / iPSCs

Biography

Jernej Ule obtained his BSc in Molecular Biology from University of Ljubljana, Slovenia and then went on to complete a PhD and postdoctoral programme with Dr Robert Darnell at The Rockefeller University (New York) before starting his own research group at the MRC Laboratory of Molecular Biology (Cambridge) in July 2006. He then moved with his team to the UCL Queen Square Institute of Neurology (London) and started a secondment as a Group Leader at the Francis Crick Institute. In April 2022, Prof Ule was appointed as Director of the UK DRI at King’s, where most of his team is now located. He also maintains a joint satellite team at the Francis Crick Institute with Prof Benjamin Blencowe to conduct research funded by the Wellcome Trust.

News

Key publications

Nature
Published
Collective homeostasis of condensation-prone proteins via their mRNAs
Authors
Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G Wilkins, Anob M Chakrabarti, Ira A Iosub, Neža Vadnjal, Rhys Dore, Lea Knez, Stefan L Ameres, Clemens Plaschka, Jernej Ule
Collective homeostasis of condensation-prone proteins via their mRNAs
Nature communications
Published
Axonal RNA localization is essential for long-term memory
Authors
Bruna R de Queiroz, Hiba Laghrissi, Seetha Rajeev, Lauren Blot, Fabienne De Graeve, Marine Dehecq, Martina Hallegger, Ugur Dag, Marion Dunoyer de Segonzac, Mirana Ramialison, Chantal Cazevieille, Krystyna Keleman, Jernej Ule, Arnaud Hubstenberger, Florence Besse
Axonal RNA localization is essential for long-term memory
BMC biology
Published
Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Ule Lab

Explore the work of the Ule Lab focused on understanding the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia.

Ule Lab
RNA