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Marc Aurel Busche profile picture

Dr Marc Aurel Busche

(MD, PhD)

Group Leader

Understanding and repairing pathological neural circuits in Alzheimer's disease

Techniques

Advanced microscopy & imaging, Electrophysiology, Experimental medicine, Human brain imaging, Mouse behaviour, Mouse in vivo imaging, Optogenetics, Stem cells / iPSCs

Biography

Dr. Marc Aurel Busche is a psychiatrist and neuroscientist at the UK Dementia Research Institute at UCL. 

His major focus is to understand the cellular and circuit mechanisms that underlie the initiation and progression of Alzheimer’s Disease (AD) and related disorders so that, through this understanding, more effective therapies can be developed. He also provides patient care as an honorary consultant psychiatrist in the cognitive disorders clinic at the Queen Square National Hospital for Neurology and Neurosurgery. 

Dr. Busche attended medical school at the Ludwig Maximilians University of Munich, and completed his clinical training in psychiatry and psychotherapy at the University Hospital of the Technical University of Munich. He performed his graduate work with Arthur Konnerth at the Technical University of Munich, carried out research as a Tandem Group Leader at the Munich Cluster for Systems Neurology and also performed an EMBO Fellowship at Massachusetts General Hospital and Harvard Medical School with Bradley Hyman. 

He is the recipient of several awards and fellowships including a UKRI Future Leaders Fellowship.

News

Key publications

The Journal of clinical investigation
Published
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection
Authors
Daniyal J Jafree, Benjamin J Stewart, Karen L Price, Maria Kolatsi-Joannou, Camille Laroche, Barian Mohidin, Benjamin Davis, Hannah Mitchell, Lauren G Russell, Lucía Marinas Del Rey, Chun Jing Wang, William J Mason, Byung Il Lee, Lauren Heptinstall, Ayshwarya Subramanian, Gideon Pomeranz, Dale Moulding, Laura Wilson, Tahmina Wickenden, Saif N Malik, Natalie Holroyd, Claire L Walsh, Jennifer C Chandler, Kevin X Cao, Paul Jd Winyard, Adrian S Woolf, Marc Aurel Busche, Simon Walker-Samuel, Lucy Sk Walker, Tessa Crompton, Peter J Scambler, Reza Motallebzadeh, Menna R Clatworthy, David A Long
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection
Cell reports
Published
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo
Authors
Samuel S Harris, Rikesh M Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland, Alexander Schmidt, Byung Il Lee, Marten Kehring, Mariam Hellmuth, Francesca Kar Wey Lam, Dominique Fässler, Susanne Erdinger, David P Wolfer, Carlo Sala Frigerio, Fred Wolf, Bradley T Hyman, Ulrike C Müller, Marc Aurel Busche
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Busche Lab

Explore the work of the Busche Lab focused on understanding and repairing pathological neural circuits in Alzheimer's disease.

Plaques and tangles in cortex in vitro