Skip to main content
Search
Main content

Dr Marc Aurel Busche

MD, PhD

Group Leader

Understanding and repairing pathological neural circuits in Alzheimer's disease

Techniques

Electrophysiology, Human brain imaging, Stem cells / iPSCs, Mouse in vivo imaging, Experimental medicine, Optogenetics, Advanced microscopy & imaging, Mouse behaviour

Biography

Dr. Marc Aurel Busche is a psychiatrist and neuroscientist at the UK Dementia Research Institute at UCL. 


His major focus is to understand the cellular and circuit mechanisms that underlie the initiation and progression of Alzheimer’s Disease (AD) and related disorders so that, through this understanding, more effective therapies can be developed. He also provides patient care as an honorary consultant psychiatrist in the cognitive disorders clinic at the Queen Square National Hospital for Neurology and Neurosurgery. 

Dr. Busche attended medical school at the Ludwig Maximilians University of Munich, and completed his clinical training in psychiatry and psychotherapy at the University Hospital of the Technical University of Munich. He performed his graduate work with Arthur Konnerth at the Technical University of Munich, carried out research as a Tandem Group Leader at the Munich Cluster for Systems Neurology and also performed an EMBO Fellowship at Massachusetts General Hospital and Harvard Medical School with Bradley Hyman.

 

He is the recipient of several awards and fellowships including a UKRI Future Leaders Fellowship.

News

Key publications

Nature neuroscience
Published
Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition
Authors
Edoardo Moretto, Anna Masato, Chiara Panzi, André T Lopes, Skye Stuart, Samantha De La-Rocque, Maria Giuseppa Caso, Ian J White, Samuel S Harris, Marc Aurel Busche, Giampietro Schiavo
Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition
Neuron
Published
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Busche Lab

Explore the work of the Busche Lab focused on understanding and repairing pathological neural circuits in Alzheimer's disease.

Plaques and tangles in cortex in vitro