Skip to main content
Search
Main content
Tim Bartels

Dr Tim Bartels

((he/him))

Group Leader

Untangling protein structure to better understand function and treat neurodegeneration

Techniques

Advanced microscopy & imaging, Advanced spectroscopy, Biophysical techniques, Experimental medicine, Flow cytometry, Fluid biomarkers, Lipidomics, Mass spec-based proteomics, Stem cells / iPSCs, Structural biology, Viral-mediated expression

Biography

Dr. Tim Bartels initially finished his MSc in Chemistry and Medical Engineering in 2005 at the Technical University Munich. In 2008 he received his PhD in Biophysics working at the Adolf Butenandt Institute (Director Christian Haass) at the Ludwig-Maximilian University (supervisors Johannes Buchner and Klaus Beyer). He completed his postdoctoral training at the Center for Neurologic Diseases/Harvard Medical School with Dennis Selkoe in 2011, where he also held his first faculty positions (Instructor of Neurology 2012-2016, assistant professor 2016-2019). 

Since 2018 he is leading the program “Structure-Function Relationship in Neurodegeneration” at the Dementia Research Institute at the University College London. His lab is dedicated to the involvement of the different forms of the presynaptic protein alpha-synuclein in Parkinson’s Disease and Dementia with Lewy Bodies. Furthermore, his lab is interested in novel context specific pathways of protein folding/misfolding and the involvement of lipids, non-neuronal cells and the gut-brain axis in neurodegeneration.   

News

Key publications

Nature
Published
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Authors
Sebastiaan De Schepper, Viktoras Konstantellos, James A Conway, Dimitra Sokolova, Ludovica Zaccagnini, Matthew V Cowley, Annerieke Sierksma, Maria Yudina, Marisa Edmonds, Daria Gavriouchkina, Bethany Geary, Amber Wallis, Meral Celikag, Zeynep Baykam, Mónica Vara-Pérez, Gerard Crowley, Fabian Tobias Hager, Mitchell Bijnen, David Posner, Kelvin Luk, Vuk Cerovic, Menna Clatworthy, Elizabeth J Videlock, Zane Jaunmuktane, Kiavash Movahedi, Melanie Greter, Benny Chain, Dario R Alessi, Soyon Hong, Tim Bartels
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
bioRxiv : the preprint server for biology
Published
Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis
Authors
Jose Cevallos, Elena Eubanks, Sunghoo Jung, Yiming Huang, Elyse Guadagno, Neeharika Rao Suvvari, Aryan Doshi, Nitya Ravinutala, Alejandro Mosera, Nagendran Ramalingam, Arati Tripathi, Tim Bartels, Ulf Dettmer, Eleanna Kara
Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis
Nature biomedical engineering
Published
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue

Bartels Lab

Explore the work of the Bartels Lab focused on untangling protein structure to better understand function and treat neurodegeneration

PET tracer imaging from the Bartels Lab