Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

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Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nat Med
Published
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.
Authors
Marie-Gabrielle Duperron, Maria J Knol, Quentin Le Grand, Tavia E Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D Dueker, Pilar Delgado, Saima Hilal, Rick M Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J Armstrong, Constance Bordes, Mark E Bastin, Alexa Beiser, Henry Brodaty, Robin Bülow, Caty Carrera, Christopher Chen, Ching-Yu Cheng, Ian J Deary, Piyush G Gampawar, Jayandra J Himali, Jiyang Jiang, Takahisa Kawaguchi, Shuo Li, Melissa Macalli, Pascale Marquis, Zoe Morris, Susana Muñoz Maniega, Susumu Miyamoto, Masakazu Okawa, Matthew Paradise, Pedram Parva, Tatjana Rundek, Muralidharan Sargurupremraj, Sabrina Schilling, Kazuya Setoh, Omar Soukarieh, Yasuharu Tabara, Alexander Teumer, Anbupalam Thalamuthu, Julian N Trollor, Maria C Valdés Hernández, Meike W Vernooij, Uwe Völker, Katharina Wittfeld, Tien Yin Wong, Margaret J Wright, Junyi Zhang, Wanting Zhao, Yi-Cheng Zhu, Helena Schmidt, Perminder S Sachdev, Wei Wen, Kazumichi Yoshida, Anne Joutel, Claudia L Satizabal, Ralph L Sacco, Guillaume Bourque, Mark Lathrop, Tomas Paus, Israel Fernandez-Cadenas, Qiong Yang, Bernard Mazoyer, Philippe Boutinaud, Yukinori Okada, Hans J Grabe, Karen A Mather, Reinhold Schmidt, Marc Joliot, M Arfan Ikram, Fumihiko Matsuda, Christophe Tzourio, Joanna M Wardlaw, Sudha Seshadri, Hieab H H Adams, Stéphanie Debette
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.
Sci Adv
Published
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.
Authors
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.
Sci Adv
Published
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.
Authors
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.
Science
Published
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Authors
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Science
Published
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Authors
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Front Cell Neurosci
Published
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Authors
Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I Rees, Denise Fitzgerald, B Paul Morgan, James W Neal, Owain W Howell
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Mol Psychiatry
Published
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.
Authors
Karen Crawford, Ganna Leonenko, Emily Baker, Detelina Grozeva, Benoit Lan-Leung, Peter Holmans, Julie Williams, Michael C O'Donovan, Valentina Escott-Price, Dobril K Ivanov
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.