Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Brain Pathol
Published
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
Authors
Benjamin J Cooze, Matthew Dickerson, Rukshikah Loganathan, Lewis M Watkins, Ethan Grounds, Ben R Pearson, Ryan Jack Bevan, B Paul Morgan, Roberta Magliozzi, Richard Reynolds, James W Neal, Owain W Howell
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
Nat Commun
Published
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Authors
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff Y L Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P J Knowles, Michele Vendruscolo, Francesco S Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Nat Commun
Published
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Authors
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff Y L Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P J Knowles, Michele Vendruscolo, Francesco S Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Acta Neuropathol
Published
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Authors
Federica Pilotto, Alexander Schmitz, Niran Maharjan, Rim Diab, Adolfo Odriozola, Priyanka Tripathi, Alfred Yamoah, Olivier Scheidegger, Angelina Oestmann, Cassandra N Dennys, Shrestha Sinha Ray, Rochelle Rodrigo, Stephen Kolb, Eleonora Aronica, Stefano Di Santo, Hans Rudolf Widmer, Nicolas Charlet-Berguerand, Bhuvaneish T Selvaraj, Siddharthan Chandran, Kathrin Meyer, Benoît Zuber, Anand Goswami, Joachim Weis, Smita Saxena
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Lancet Healthy Longev
Published
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.
Authors
Aaron Z Wagen, William Coath, Ashvini Keshavan, Sarah-Naomi James, Thomas D Parker, Christopher A Lane, Sarah M Buchanan, Sarah E Keuss, Mathew Storey, Kirsty Lu, Amy Macdougall, Heidi Murray-Smith, Tamar Freiberger, David M Cash, Ian B Malone, Josephine Barnes, Carole H Sudre, Andrew Wong, Ivanna M Pavisic, Rebecca Street, Sebastian J Crutch, Valentina Escott-Price, Ganna Leonenko, Henrik Zetterberg, Henrietta Wellington, Amanda Heslegrave, Frederik Barkhof, Marcus Richards, Nick C Fox, James H Cole, Jonathan M Schott
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.
Lancet Healthy Longev
Published
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.
Authors
Aaron Z Wagen, William Coath, Ashvini Keshavan, Sarah-Naomi James, Thomas D Parker, Christopher A Lane, Sarah M Buchanan, Sarah E Keuss, Mathew Storey, Kirsty Lu, Amy Macdougall, Heidi Murray-Smith, Tamar Freiberger, David M Cash, Ian B Malone, Josephine Barnes, Carole H Sudre, Andrew Wong, Ivanna M Pavisic, Rebecca Street, Sebastian J Crutch, Valentina Escott-Price, Ganna Leonenko, Henrik Zetterberg, Henrietta Wellington, Amanda Heslegrave, Frederik Barkhof, Marcus Richards, Nick C Fox, James H Cole, Jonathan M Schott
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.
NPJ Genom Med
Published
Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1.
Authors
Sergey V Lobanov, Branduff McAllister, Mia McDade-Kumar, G Bernhard Landwehrmeyer, Michael Orth, Anne E Rosser, Jane S Paulsen, Jong-Min Lee, Marcy E MacDonald, James F Gusella, Jeffrey D Long, Mina Ryten, Nigel M Williams, Peter Holmans, Thomas H Massey, Lesley Jones
Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1.
NPJ Genom Med
Published
Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1.
Authors
Sergey V Lobanov, Branduff McAllister, Mia McDade-Kumar, G Bernhard Landwehrmeyer, Michael Orth, Anne E Rosser, , Jane S Paulsen, , Jong-Min Lee, Marcy E MacDonald, James F Gusella, Jeffrey D Long, Mina Ryten, Nigel M Williams, Peter Holmans, Thomas H Massey, Lesley Jones
Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1.