Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Science
Published
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Authors
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Science
Published
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Authors
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Front Cell Neurosci
Published
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Authors
Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I Rees, Denise Fitzgerald, B Paul Morgan, James W Neal, Owain W Howell
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Mol Psychiatry
Published
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.
Authors
Karen Crawford, Ganna Leonenko, Emily Baker, Detelina Grozeva, Benoit Lan-Leung, Peter Holmans, Julie Williams, Michael C O'Donovan, Valentina Escott-Price, Dobril K Ivanov
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.
JMIR Aging
Published
Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.
Authors
Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott
Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.
Nat Neurosci
Published
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
Authors
Sebastiaan De Schepper, Judy Z Ge, Annerieke Sierksma, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
JMIR Aging
Published
Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.
Authors
Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott
Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.
Int J Mol Sci
Published
Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer's Disease Model Mice and the SH-SY5Y Neuronal Cell Line.
Authors
Thomas S Webberley, Ryan J Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R Michael, Sophie Thomas, Meg Rees, James E Morgan, Julian R Marchesi, Mark A Good, Sue F Plummer, Duolao Wang, Timothy R Hughes
Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer's Disease Model Mice and the SH-SY5Y Neuronal Cell Line.