Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Neuron

Published May 21, 2014

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Authors

Tara L Spires-Jones, Bradley T Hyman

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Science

Published May 09, 2014

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Authors

Marcela Rosas, Luke C Davies, Peter J Giles, Chia-Te Liao, Bashar Kharfan, Timothy C Stone, Valerie B O'Donnell, Donald J Fraser, Simon A Jones, Philip R Taylor

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Neuron

Published Apr 16, 2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Authors

Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin, Katsuhiko Yanagisawa, Shaomin Li, Tim Bartels, Dennis J Selkoe

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Neuron

Published Apr 16, 2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Authors

Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin, Katsuhiko Yanagisawa, Shaomin Li, Tim Bartels, Dennis J Selkoe

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Science

Published Apr 11, 2014

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors

Vanessa A Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Science

Published Apr 11, 2014

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Nature

Published Apr 03, 2014

Capillary pericytes regulate cerebral blood flow in health and disease.

Authors

Catherine N Hall, Clare Reynell, Bodil Gesslein, Nicola B Hamilton, Anusha Mishra, Brad A Sutherland, Fergus M O'Farrell, Alastair M Buchan, Martin Lauritzen, David Attwell

Capillary pericytes regulate cerebral blood flow in health and disease.

Nature

Published Apr 03, 2014

Capillary pericytes regulate cerebral blood flow in health and disease.

Authors

Catherine N Hall, Clare Reynell, Bodil Gesslein, Nicola B Hamilton, Anusha Mishra, Brad A Sutherland, Fergus M O'Farrell, Alastair M Buchan, Martin Lauritzen, David Attwell

Capillary pericytes regulate cerebral blood flow in health and disease.

N Engl J Med

Published Mar 27, 2014

Thrombotic microangiopathy associated with interferon beta.

Authors

David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran

Thrombotic microangiopathy associated with interferon beta.

N Engl J Med

Published Mar 27, 2014

Thrombotic microangiopathy associated with interferon beta.

Authors

David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran

Thrombotic microangiopathy associated with interferon beta.

Nat Neurosci

Published Feb 24, 2014

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Authors

Usman A Khan, Li Liu, Frank A Provenzano, Diego E Berman, Caterina P Profaci, Richard Sloan, Richard Mayeux, Karen E Duff, Scott A Small

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

N Engl J Med

Published Jan 23, 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Authors

Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H Robert Brashear,

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Acta Neuropathol

Published Dec 10, 2013

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Authors

Sarah Mizielinska, Tammaryn Lashley, Frances E Norona, Emma L Clayton, Charlotte E Ridler, Pietro Fratta, Adrian M Isaacs

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Acta Neuropathol

Published Oct 30, 2013

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Authors

Sarah Mizielinska, Tammaryn Lashley, Frances E Norona, Emma L Clayton, Charlotte E Ridler, Pietro Fratta, Adrian M Isaacs

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Lancet Neurol

Published Aug 19, 2013

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Authors

Joanna M Wardlaw, Eric E Smith, Geert J Biessels, Charlotte Cordonnier, Franz Fazekas, Richard Frayne, Richard I Lindley, John T O'Brien, Frederik Barkhof, Oscar R Benavente, Sandra E Black, Carol Brayne, Monique Breteler, Hugues Chabriat, Charles Decarli, Frank-Erik de Leeuw, Fergus Doubal, Marco Duering, Nick C Fox, Steven Greenberg, Vladimir Hachinski, Ingo Kilimann, Vincent Mok, Robert van Oostenbrugge, Leonardo Pantoni, Oliver Speck, Blossom C M Stephan, Stefan Teipel, Anand Viswanathan, David Werring, Christopher Chen, Colin Smith, Mark van Buchem, Bo Norrving, Philip B Gorelick, Martin Dichgans

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Nat Neurosci

Published Jul 21, 2013

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Authors

Veronique E Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J Yuen, Julia M Ruckh, Jennifer L Shadrach, Peter van Wijngaarden, Amy J Wagers, Anna Williams, Robin J M Franklin, Charles Ffrench-Constant

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.