Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Cell

Published May 25, 2012

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Authors

Nunilo Cremades, Samuel I A Cohen, Emma Deas, Andrey Y Abramov, Allen Y Chen, Angel Orte, Massimo Sandal, Richard W Clarke, Paul Dunne, Francesco A Aprile, Carlos W Bertoncini, Nicholas W Wood, Tuomas P J Knowles, Christopher M Dobson, David Klenerman

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Cell

Published May 25, 2012

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Authors

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Nat Cell Biol

Published Apr 08, 2012

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Authors

Vincent Dion, Véronique Kalck, Chihiro Horigome, Benjamin D Towbin, Susan M Gasser

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Nat Cell Biol

Published Apr 08, 2012

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Authors

Vincent Dion, Véronique Kalck, Chihiro Horigome, Benjamin D Towbin, Susan M Gasser

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Nat Neurosci

Published Jan 29, 2012

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Authors

Iryna Benilova, Eric Karran, Bart De Strooper

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Nat Neurosci

Published Jan 29, 2012

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Authors

Iryna Benilova, Eric Karran, Bart De Strooper

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Nat Struct Mol Biol

Published Dec 18, 2011

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Authors

Priyanka Narayan, Angel Orte, Richard W Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A Ganzinger, Sarah Meehan, Mark R Wilson, Christopher M Dobson, David Klenerman

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Nat Struct Mol Biol

Published Dec 18, 2011

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Authors

Priyanka Narayan, Angel Orte, Richard W Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A Ganzinger, Sarah Meehan, Mark R Wilson, Christopher M Dobson, David Klenerman

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

IEEE Int Conf Rehabil Robot

Published Jul 01, 2011

Estimation of IMU and MARG orientation using a gradient descent algorithm.

Authors

Sebastian O H Madgwick, Andrew J L Harrison, Andrew Vaidyanathan

Estimation of IMU and MARG orientation using a gradient descent algorithm.

IEEE Trans Biomed Eng

Published Jun 15, 2011

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Authors

Nir Grossman, Konstantin Nikolic, Christofer Toumazou, Patrick Degenaar

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Ann Neurol

Published Apr 18, 2011

Inflammation after trauma: microglial activation and traumatic brain injury.

Authors

Anil F Ramlackhansingh, David J Brooks, Richard J Greenwood, Subrata K Bose, Federico E Turkheimer, Kirsi M Kinnunen, Steve Gentleman, Rolf A Heckemann, Karen Gunanayagam, Giorgio Gelosa, David J Sharp

Inflammation after trauma: microglial activation and traumatic brain injury.

J Neurosci

Published Mar 02, 2011

Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control.

Authors

Robert Leech, Salwa Kamourieh, Christian F Beckmann, David J Sharp

Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control.

IEEE Trans Biomed Eng

Published Feb 14, 2011

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Authors

Nir Grossman, Konstantin Nikolic, Christofer Toumazou, Patrick Degenaar

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Brain

Published Dec 30, 2010

White matter damage and cognitive impairment after traumatic brain injury.

Authors

Kirsi Maria Kinnunen, Richard Greenwood, Jane Hilary Powell, Robert Leech, Peter Charlie Hawkins, Valerie Bonnelle, Maneesh Chandrakant Patel, Serena Jane Counsell, David James Sharp

White matter damage and cognitive impairment after traumatic brain injury.

Neuron

Published Jul 29, 2010

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Authors

Patricio Opazo, Simon Labrecque, Cezar M Tigaret, Arnaud Frouin, Paul W Wiseman, Paul De Koninck, Daniel Choquet

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Neuron

Published Jul 29, 2010

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Authors

Patricio Opazo, Simon Labrecque, Cezar M Tigaret, Arnaud Frouin, Paul W Wiseman, Paul De Koninck, Daniel Choquet

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Nature

Published Apr 22, 2010

Caspase activation precedes and leads to tangles.

Authors

Alix de Calignon, Leora M Fox, Rose Pitstick, George A Carlson, Brian J Bacskai, Tara L Spires-Jones, Bradley T Hyman

Caspase activation precedes and leads to tangles.

Nature

Published Mar 31, 2010

Caspase activation precedes and leads to tangles

Authors

Alix de Calignon, Leora M. Fox, Rose Pitstick, George A. Carlson, Brian J. Bacskai, Tara L. Spires-Jones, Bradley T. Hyman

Caspase activation precedes and leads to tangles