Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Lancet Neurol
Published
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.
Authors
Christopher A Lane, Josephine Barnes, Jennifer M Nicholas, Carole H Sudre, David M Cash, Thomas D Parker, Ian B Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Heidi Murray-Smith, Andrew Wong, Sarah M Buchanan, Sarah E Keuss, Elizabeth Gordon, William Coath, Anna Barnes, John Dickson, Marc Modat, David Thomas, Sebastian J Crutch, Rebecca Hardy, Marcus Richards, Nick C Fox, Jonathan M Schott
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.
Brain
Published
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Authors
Renzo Mancuso, Gemma Fryatt, Madeleine Cleal, Juliane Obst, Elena Pipi, Jimena Monzón-Sandoval, Elena Ribe, Laura Winchester, Caleb Webber, Alejo Nevado, Tom Jacobs, Nigel Austin, Clara Theunis, Karolien Grauwen, Eva Daniela Ruiz, Amrit Mudher, Marta Vicente-Rodriguez, Christine A Parker, Camilla Simmons, Diana Cash, Jill Richardson, Declan N C Jones, Simon Lovestone, Diego Gómez-Nicola, V Hugh Perry
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mol Psychiatry
Published
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Authors
Navneet A Vasistha, Mandy Johnstone, Samantha K Barton, Steffen E Mayerl, Bhuvaneish Thangaraj Selvaraj, Pippa A Thomson, Owen Dando, Ellen Grünewald, Clara Alloza, Mark E Bastin, Matthew R Livesey, Kyriakos Economides, Dario Magnani, Paraskevi Makedonopolou, Karen Burr, David J Story, Douglas H R Blackwood, David J A Wyllie, Andrew M McIntosh, J Kirsty Millar, Charles Ffrench-Constant, Giles E Hardingham, Stephen M Lawrie, Siddharthan Chandran
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Nat Protoc
Published
Derivation and maintenance of mouse haploid embryonic stem cells.
Authors
Ulrich Elling, Michael Woods, Josep V Forment, Beiyuan Fu, Fengtang Yang, Bee Ling Ng, Jose R Vicente, David J Adams, Brendan Doe, Stephen P Jackson, Josef M Penninger, Gabriel Balmus
Derivation and maintenance of mouse haploid embryonic stem cells.
Science
Published
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Authors
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Science
Published
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Authors
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nat Neurosci
Published
Central nervous system regeneration is driven by microglia necroptosis and repopulation.
Authors
Amy F Lloyd, Claire L Davies, Rebecca K Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W Pollard, Anne des Rieux, Josef Priller, Veronique E Miron
Central nervous system regeneration is driven by microglia necroptosis and repopulation.
Nat Protoc
Published
Derivation and maintenance of mouse haploid embryonic stem cells.
Authors
Ulrich Elling, Michael Woods, Josep V Forment, Beiyuan Fu, Fengtang Yang, Bee Ling Ng, Jose R Vicente, David J Adams, Brendan Doe, Stephen P Jackson, Josef M Penninger, Gabriel Balmus
Derivation and maintenance of mouse haploid embryonic stem cells.
PLoS Pathog
Published
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.
Authors
Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.