Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Nat Genet

Published May 21, 2018

Genetic identification of brain cell types underlying schizophrenia.

Authors

Nathan G Skene, Julien Bryois, Trygve E Bakken, Gerome Breen, James J Crowley, Héléna A Gaspar, Paola Giusti-Rodriguez, Rebecca D Hodge, Jeremy A Miller, Ana B Muñoz-Manchado, Michael C O'Donovan, Michael J Owen, Antonio F Pardiñas, Jesper Ryge, James T R Walters, Sten Linnarsson, Ed S Lein, , Patrick F Sullivan, Jens Hjerling-Leffler

Genetic identification of brain cell types underlying schizophrenia.

Nat Commun

Published Apr 27, 2018

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Authors

Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, , David J Adams, Stephen P Jackson

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Nat Commun

Published Apr 27, 2018

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Authors

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

FASEB J

Published Apr 11, 2018

IKK2/NF-κB signaling protects neurons after traumatic brain injury.

Authors

Melanie Mettang, Stephanie Nadine Reichel, Michael Lattke, Annette Palmer, Alireza Abaei, Volker Rasche, Markus Huber-Lang, Bernd Baumann, Thomas Wirth

IKK2/NF-κB signaling protects neurons after traumatic brain injury.

Dev Cell

Published Apr 09, 2018

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.

Authors

Claudia Puri, Mariella Vicinanza, Avraham Ashkenazi, Matthew J Gratian, Qifeng Zhang, Carla F Bento, Maurizio Renna, Fiona M Menzies, David C Rubinsztein

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.

Science

Published Mar 09, 2018

Local transformations of the hippocampal cognitive map.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, John O'Keefe

Local transformations of the hippocampal cognitive map.

Science

Published Mar 09, 2018

Local transformations of the hippocampal cognitive map.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, John O'Keefe

Local transformations of the hippocampal cognitive map.

Acta Neuropathol

Published Mar 01, 2018

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Authors

Thomas G Moens, Sarah Mizielinska, Teresa Niccoli, Jamie S Mitchell, Annora Thoeng, Charlotte E Ridler, Sebastian Grönke, Jacqueline Esser, Amanda Heslegrave, Henrik Zetterberg, Linda Partridge, Adrian M Isaacs

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Structure

Published Feb 06, 2018

Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.

Authors

Osman Salih, Shaoda He, Sara Planamente, Lasse Stach, James T MacDonald, Eleni Manoli, Sjors H W Scheres, Alain Filloux, Paul S Freemont

Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.

Acta Neuropathol

Published Feb 03, 2018

Activin receptors regulate the oligodendrocyte lineage in health and disease.

Authors

Alessandra Dillenburg, Graeme Ireland, Rebecca K Holloway, Claire L Davies, Frances L Evans, Matthew Swire, Marie E Bechler, Daniel Soong, Tracy J Yuen, Gloria H Su, Julie-Clare Becher, Colin Smith, Anna Williams, Veronique E Miron

Activin receptors regulate the oligodendrocyte lineage in health and disease.

Lancet Neurol

Published Feb 01, 2018

Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study.

Authors

Philip S J Weston, Jennifer M Nicholas, Susie M D Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M Schott, Martin N Rossor, Sebastian J Crutch, Christopher R Butler, Adam Z Zeman, Nick C Fox

Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study.

Nature

Published Feb 01, 2018

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation.

Authors

Ruth A Wood, Marius Bauza, Julija Krupic, Stephen Burton, Andrea Delekate, Dennis Chan, John O'Keefe

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation.

Dis Model Mech

Published Jan 30, 2018

The central role of DNA damage and repair in CAG repeat diseases.

Authors

Thomas H Massey, Lesley Jones

The central role of DNA damage and repair in CAG repeat diseases.

Acta Neuropathol

Published Jan 29, 2018

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Authors

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

EMBO Mol Med

Published Jan 28, 2018

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Authors

Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert-Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie-Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Nat Commun

Published Jan 24, 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Authors

Bhuvaneish T Selvaraj, Matthew R Livesey, Chen Zhao, Jenna M Gregory, Owain T James, Elaine M Cleary, Amit K Chouhan, Angus B Gane, Emma M Perkins, Owen Dando, Simon G Lillico, Youn-Bok Lee, Agnes L Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E Shaw, Peter C Kind, Timothy J Aitman, C Bruce A Whitelaw, Ian Wilmut, Colin Smith, Gareth B Miles, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Nat Commun

Published Jan 24, 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Authors

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Neuron

Published Jan 17, 2018

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.

Authors

Christian Madry, Vasiliki Kyrargyri, I Lorena Arancibia-Cárcamo, Renaud Jolivet, Shinichi Kohsaka, Robert M Bryan, David Attwell

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.