Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

BMC Biol

Published Mar 27, 2017

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Authors

Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F Kaminski, David Ron, Edward Avezov

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

BMC Biol

Published Mar 27, 2017

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Authors

Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F Kaminski, David Ron, Edward Avezov

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Neuron

Published Mar 22, 2017

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Authors

Marco Brancaccio, Andrew P Patton, Johanna E Chesham, Elizabeth S Maywood, Michael H Hastings

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Neuron

Published Mar 22, 2017

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Authors

Marco Brancaccio, Andrew P Patton, Johanna E Chesham, Elizabeth S Maywood, Michael H Hastings

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Neuron

Published Mar 08, 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Authors

Ira Espuny-Camacho, Amaia M Arranz, Mark Fiers, An Snellinx, Kunie Ando, Sebastian Munck, Jerome Bonnefont, Laurie Lambot, Nikky Corthout, Lorna Omodho, Elke Vanden Eynden, Enrico Radaelli, Ina Tesseur, Selina Wray, Andreas Ebneth, John Hardy, Karelle Leroy, Jean-Pierre Brion, Pierre Vanderhaeghen, Bart De Strooper

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Neuron

Published Mar 08, 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Authors

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Front Cell Neurosci

Published Mar 02, 2017

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB.

Authors

Rosie Owens, Kathleen Grabert, Claire L Davies, Alessio Alfieri, Jack P Antel, Luke M Healy, Barry W McColl

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB.

Mol Neurodegener

Published Feb 13, 2017

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration.

Authors

Michael Lattke, Stephanie N Reichel, Alexander Magnutzki, Alireza Abaei, Volker Rasche, Paul Walther, Dinis P Calado, Boris Ferger, Thomas Wirth, Bernd Baumann

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration.

Neuron

Published Feb 08, 2017

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Authors

Hongjun Fu, Gustavo A Rodriguez, Mathieu Herman, Sheina Emrani, Eden Nahmani, Geoffrey Barrett, Helen Y Figueroa, Eliana Goldberg, S Abid Hussaini, Karen E Duff

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Hum Mol Genet

Published Feb 01, 2017

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Authors

Cynthia Sandor, Paul Robertson, Charmaine Lang, Andreas Heger, Heather Booth, Jane Vowles, Lorna Witty, Rory Bowden, Michele Hu, Sally A Cowley, Richard Wade-Martins, Caleb Webber

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Hum Mol Genet

Published Feb 01, 2017

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Authors

Cynthia Sandor, Paul Robertson, Charmaine Lang, Andreas Heger, Heather Booth, Jane Vowles, Lorna Witty, Rory Bowden, Michele Hu, Sally A Cowley, Richard Wade-Martins, Caleb Webber

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Nature

Published Jan 25, 2017

PLD3 gene and processing of APP.

Authors

Pietro Fazzari, Katrien Horre, Amaia M Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C Saido, Bart De Strooper

PLD3 gene and processing of APP.

Nature

Published Jan 25, 2017

PLD3 gene and processing of APP.

Authors

Pietro Fazzari, Katrien Horre, Amaia M Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C Saido, Bart De Strooper

PLD3 gene and processing of APP.

Neuron

Published Jan 18, 2017

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Authors

Jian Gan, Shih-Ming Weng, Alejandro J Pernía-Andrade, Jozsef Csicsvari, Peter Jonas

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Neuron

Published Jan 18, 2017

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Authors

Jian Gan, Shih-Ming Weng, Alejandro J Pernía-Andrade, Jozsef Csicsvari, Peter Jonas

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Wellcome Open Res

Published Jan 01, 2017

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

Authors

Sarah McGlasson, Kristiina Rannikmäe, Steven Bevan, Clare Logan, Louise S Bicknell, Alexa Jury, Andrew P Jackson, Hugh S Markus, Cathie Sudlow, David P J Hunt

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

Lancet Neurol

Published Dec 29, 2016

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Authors

Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Blood

Published Dec 15, 2016

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Authors

David Kavanagh, Sarah McGlasson, Alexa Jury, Jac Williams, Neil Scolding, Chris Bellamy, Claudia Gunther, Diane Ritchie, Daniel P Gale, Yashpal S Kanwar, Rachel Challis, Holly Buist, James Overell, Belinda Weller, Oliver Flossmann, Mark Blunden, Eric P Meyer, Thomas Krucker, Stephen J W Evans, Iain L Campbell, Andrew P Jackson, Siddharthan Chandran, David P J Hunt

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.