Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Neuron

Published Apr 20, 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Authors

Sarah Veugelen, Takashi Saito, Takaomi C Saido, Lucía Chávez-Gutiérrez, Bart De Strooper

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Neuron

Published Apr 20, 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Authors

Sarah Veugelen, Takashi Saito, Takaomi C Saido, Lucía Chávez-Gutiérrez, Bart De Strooper

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Cereb Cortex

Published Apr 13, 2016

Anatomical Abnormalities in Autism?

Authors

Shlomi Haar, Sigal Berman, Marlene Behrmann, Ilan Dinstein

Anatomical Abnormalities in Autism?

Proc Natl Acad Sci U S A

Published Apr 12, 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Authors

Uthpala Seneviratne, Alexi Nott, Vadiraja B Bhat, Kodihalli C Ravindra, John S Wishnok, Li-Huei Tsai, Steven R Tannenbaum

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Proc Natl Acad Sci U S A

Published Apr 12, 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Authors

Uthpala Seneviratne, Alexi Nott, Vadiraja B Bhat, Kodihalli C Ravindra, John S Wishnok, Li-Huei Tsai, Steven R Tannenbaum

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Trends Neurosci

Published Mar 13, 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Authors

Soraia Barão, Diederik Moechars, Stefan F Lichtenthaler, Bart De Strooper

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Trends Neurosci

Published Mar 01, 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Authors

Soraia Barão, Diederik Moechars, Stefan F Lichtenthaler, Bart De Strooper

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Cell

Published Feb 11, 2016

The Cellular Phase of Alzheimer's Disease.

Authors

Bart De Strooper, Eric Karran

The Cellular Phase of Alzheimer's Disease.

Cell

Published Feb 11, 2016

The Cellular Phase of Alzheimer's Disease.

Authors

Bart De Strooper, Eric Karran

The Cellular Phase of Alzheimer's Disease.

Front Neurosci

Published Jan 27, 2016

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Authors

Nathan G Skene, Seth G N Grant

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Nat Neurosci

Published Jan 18, 2016

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Authors

Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers, Barry W McColl

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Nat Med

Published Dec 21, 2015

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Authors

Natura Myeku, Catherine L Clelland, Sheina Emrani, Nikolay V Kukushkin, Wai Haung Yu, Alfred L Goldberg, Karen E Duff

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

J Cell Biol

Published Oct 26, 2015

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Authors

Tasuku Konno, Eduardo Pinho Melo, Carlos Lopes, Ilir Mehmeti, Sigurd Lenzen, David Ron, Edward Avezov

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

J Cell Biol

Published Oct 26, 2015

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Authors

Tasuku Konno, Eduardo Pinho Melo, Carlos Lopes, Ilir Mehmeti, Sigurd Lenzen, David Ron, Edward Avezov

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Nat Rev Neurosci

Published Sep 16, 2015

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Authors

Frances K Wiseman, Tamara Al-Janabi, John Hardy, Annette Karmiloff-Smith, Dean Nizetic, Victor L J Tybulewicz, Elizabeth M C Fisher, André Strydom

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Cell

Published Jul 30, 2015

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Authors

Michael J Parsons, Marco Brancaccio, Siddharth Sethi, Elizabeth S Maywood, Rahul Satija, Jessica K Edwards, Aarti Jagannath, Yvonne Couch, Mattéa J Finelli, Nicola J Smyllie, Christopher Esapa, Rachel Butler, Alun R Barnard, Johanna E Chesham, Shoko Saito, Greg Joynson, Sara Wells, Russell G Foster, Peter L Oliver, Michelle M Simon, Ann-Marie Mallon, Michael H Hastings, Patrick M Nolan

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.