Publications

Featured

Oct 31, 2024 - Research

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein...

Learn more Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

Two people sit in wheelchairs next to one another

Sep 19, 2024 - Research

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

The first results from the innovative platform trial, MND-SMART, have been published in the journal The Lancet Neurology today. Led by Prof Siddharthan Chandran (UK...

Learn more First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Illustration of the inside of a blood vessel

Sep 18, 2024 - Research

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

A new mouse study led by Prof David Attwell (BHF-UK DRI Centre for Vascular Dementia Research) has found that a repurposed drug could reverse the...

Learn more Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Acta Neuropathol Commun

Published Mar 17, 2020

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.

Authors

Alexander M Rossor, James N Sleigh, Michael Groves, Francesco Muntoni, Mary M Reilly, Casper C Hoogenraad, Giampietro Schiavo

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.

Cell Rep

Published Mar 17, 2020

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

Authors

James N Sleigh, Andrew P Tosolini, David Gordon, Anny Devoy, Pietro Fratta, Elizabeth M C Fisher, Kevin Talbot, Giampietro Schiavo

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

EMBO Rep

Published Mar 04, 2020

IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.

Authors

Alexander D Fellows, Elena R Rhymes, Katherine L Gibbs, Linda Greensmith, Giampietro Schiavo

IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.

Nat Genet

Published Feb 29, 2020

A small molecule kicks repeat expansion into reverse.

Authors

Michael D Flower, Sarah J Tabrizi

A small molecule kicks repeat expansion into reverse.

Cell Death Dis

Published Feb 06, 2020

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Authors

Claire S Durrant, Karsten Ruscher, Olivia Sheppard, Michael P Coleman, Ilknur Özen

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Nat Commun

Published Dec 12, 2019

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.

Authors

Thomas Knöpfel, Yann Sweeney, Carola I Radulescu, Nawal Zabouri, Nazanin Doostdar, Claudia Clopath, Samuel J Barnes

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.

Science

Published Nov 29, 2019

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Authors

Alexi Nott, Inge R Holtman, Nicole G Coufal, Johannes C M Schlachetzki, Miao Yu, Rong Hu, Claudia Z Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, Martina P Pasillas, Carolyn O'Connor, Christian K Nickl, Simon T Schafer, Zeyang Shen, Robert A Rissman, James B Brewer, David Gosselin, David D Gonda, Michael L Levy, Michael G Rosenfeld, Graham McVicker, Fred H Gage, Bing Ren, Christopher K Glass

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Sci Transl Med

Published Oct 16, 2019

Astrocyte molecular signatures in Huntington's disease.

Authors

Blanca Diaz-Castro, Mohitkumar R Gangwani, Xinzhu Yu, Giovanni Coppola, Baljit S Khakh

Astrocyte molecular signatures in Huntington's disease.

Cell

Published Aug 08, 2019

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset.

Authors

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset.

Mol Psychiatry

Published Jul 24, 2019

Epigenetics in eating disorders: a systematic review.

Authors

Christopher Hübel, Sarah J Marzi, Gerome Breen, Cynthia M Bulik

Epigenetics in eating disorders: a systematic review.

Science

Published Jul 19, 2019

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Authors

Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Science

Published Jul 05, 2019

Targeting microglia in brain disorders.

Authors

Josef Priller, Marco Prinz

Targeting microglia in brain disorders.

J Biol Chem

Published Jun 21, 2019

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Authors

Matteo Rovere, Alex E Powers, Haiyang Jiang, Julia C Pitino, Luis Fonseca-Ornelas, Dushyant S Patel, Alessandro Achille, Ralf Langen, Jobin Varkey, Tim Bartels

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Brain

Published Jun 19, 2019

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

Authors

Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, , , Darren G Monckton, Sarah J Tabrizi

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

N Engl J Med

Published Jun 13, 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Authors

Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards, Anne Rosser, Holly B Kordasiewicz, Christian Czech, Eric E Swayze, Daniel A Norris, Tiffany Baumann, Irene Gerlach, Scott A Schobel, Erika Paz, Anne V Smith, C Frank Bennett, Roger M Lane,

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Sci Transl Med

Published May 29, 2019

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Authors

Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools, Bart de Strooper

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

J Neuroinflammation

Published May 18, 2019

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.

Authors

Olivia Sheppard, Michael P Coleman, Claire S Durrant

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.

Neuron

Published Mar 06, 2019

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Authors

Sarah J Tabrizi, Rhia Ghosh, Blair R Leavitt

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Shaping the future of dementia research: Meet the UK DRI’s newest Emerging Leaders

Why partner with the UK DRI?

Why join the UK DRI?

Publications

Featured

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.

A small molecule kicks repeat expansion into reverse.

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex.

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Astrocyte molecular signatures in Huntington's disease.

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset.

Epigenetics in eating disorders: a systematic review.

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Targeting microglia in brain disorders.

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.