Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nature
Published

Microglia regulate central nervous system myelin growth and integrity.

Authors
Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron
Microglia regulate central nervous system myelin growth and integrity.
Nature
Published

Microglia regulate central nervous system myelin growth and integrity.

Authors
Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron
Microglia regulate central nervous system myelin growth and integrity.
Ann Neurol
Published

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

Authors
Maura Malpetti, P Simon Jones, Thomas E Cope, Negin Holland, Michelle Naessens, Matthew A Rouse, Timothy Rittman, George Savulich, David J Whiteside, Duncan Street, Tim D Fryer, Young T Hong, Selena Milicevic Sephton, Franklin I Aigbirhio, John T O Brien, James B Rowe
Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.
Ann Neurol
Published

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

Authors
Maura Malpetti, P Simon Jones, Thomas E Cope, Negin Holland, Michelle Naessens, Matthew A Rouse, Timothy Rittman, George Savulich, David J Whiteside, Duncan Street, Tim D Fryer, Young T Hong, Selena Milicevic Sephton, Franklin I Aigbirhio, John T O Brien, James B Rowe
Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.
Nucleic Acids Res
Published

IntroVerse: a comprehensive database of introns across human tissues.

Authors
Sonia García-Ruiz, Emil K Gustavsson, David Zhang, Regina H Reynolds, Zhongbo Chen, Aine Fairbrother-Browne, Ana Luisa Gil-Martínez, Juan A Botia, Leonardo Collado-Torres, Mina Ryten
IntroVerse: a comprehensive database of introns across human tissues.
Nucleic Acids Res
Published

IntroVerse: a comprehensive database of introns across human tissues.

Authors
Sonia García-Ruiz, Emil K Gustavsson, David Zhang, Regina H Reynolds, Zhongbo Chen, Aine Fairbrother-Browne, Ana Luisa Gil-Martínez, Juan A Botia, Leonardo Collado-Torres, Mina Ryten
IntroVerse: a comprehensive database of introns across human tissues.
Brain Commun
Published

Predictive blood biomarkers and brain changes associated with age-related cognitive decline.

Authors
Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L Spires-Jones
Predictive blood biomarkers and brain changes associated with age-related cognitive decline.
Cereb Circ Cogn Behav
Published

A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.

Authors
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, Mlj Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Mol Psychiatry
Published

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.

Authors
Karen Crawford, Ganna Leonenko, Emily Baker, Detelina Grozeva, Benoit Lan-Leung, Peter Holmans, Julie Williams, Michael C O'Donovan, Valentina Escott-Price, Dobril K Ivanov
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.
Nature Reviews Neurology
Published

Synaptic degeneration in Alzheimer disease

Authors
Makis Tzioras, Robert I. McGeachan, Claire S. Durrant, Tara L Spires-Jones
Synaptic degeneration in Alzheimer disease