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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nat Struct Mol Biol
Published
Target-induced clustering activates Trim-Away of pathogens and proteins.
Authors
Jingwei Zeng, Ana Filipa Santos, Aamir S Mukadam, Mariana Osswald, David A Jacques, Claire F Dickson, Stephen H McLaughlin, Christopher M Johnson, Leo Kiss, Jakub Luptak, Nadine Renner, Marina Vaysburd, William A McEwan, Eurico Morais-de-Sá, Dean Clift, Leo C James
Target-induced clustering activates Trim-Away of pathogens and proteins.
Elife
Published
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Authors
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Mol Neurodegener
Published
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Authors
Emma M Perkins, Karen Burr, Poulomi Banerjee, Arpan R Mehta, Owen Dando, Bhuvaneish T Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M Henstridge, Thomas H Gillingwater, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran, Matthew R Livesey
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Lancet Neurol
Published
New insights into atypical Alzheimer's disease in the era of biomarkers.
Authors
Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray
New insights into atypical Alzheimer's disease in the era of biomarkers.
Brain
Published
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
Authors
Ashvini Keshavan, Josef Pannee, Thomas K Karikari, Juan Lantero Rodriguez, Nicholas J Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
Nat Neurosci
Published
Reactive astrocyte nomenclature, definitions, and future directions.
Authors
Carole Escartin, Elena Galea, András Lakatos, James P O'Callaghan, Gabor C Petzold, Alberto Serrano-Pozo, Christian Steinhäuser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, Nicola J Allen, Alfonso Araque, Luis Barbeito, Ari Barzilai, Dwight E Bergles, Gilles Bonvento, Arthur M Butt, Wei-Ting Chen, Martine Cohen-Salmon, Colm Cunningham, Benjamin Deneen, Bart De Strooper, Blanca Díaz-Castro, Cinthia Farina, Marc Freeman, Vittorio Gallo, James E Goldman, Steven A Goldman, Magdalena Götz, Antonia Gutiérrez, Philip G Haydon, Dieter H Heiland, Elly M Hol, Matthew G Holt, Masamitsu Iino, Ksenia V Kastanenka, Helmut Kettenmann, Baljit S Khakh, Schuichi Koizumi, C Justin Lee, Shane A Liddelow, Brian A MacVicar, Pierre Magistretti, Albee Messing, Anusha Mishra, Anna V Molofsky, Keith K Murai, Christopher M Norris, Seiji Okada, Stéphane H R Oliet, João F Oliveira, Aude Panatier, Vladimir Parpura, Marcela Pekna, Milos Pekny, Luc Pellerin, Gertrudis Perea, Beatriz G Pérez-Nievas, Frank W Pfrieger, Kira E Poskanzer, Francisco J Quintana, Richard M Ransohoff, Miriam Riquelme-Perez, Stefanie Robel, Christine R Rose, Jeffrey D Rothstein, Nathalie Rouach, David H Rowitch, Alexey Semyanov, Swetlana Sirko, Harald Sontheimer, Raymond A Swanson, Javier Vitorica, Ina-Beate Wanner, Levi B Wood, Jiaqian Wu, Binhai Zheng, Eduardo R Zimmer, Robert Zorec, Michael V Sofroniew, Alexei Verkhratsky
Reactive astrocyte nomenclature, definitions, and future directions.
J Neurol Neurosurg Psychiatry
Published
Fluid biomarkers in frontotemporal dementia: past, present and future.
Authors
Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer
Fluid biomarkers in frontotemporal dementia: past, present and future.