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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

J Exp Med
Published
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
Authors
Mathieu P Rodero, Jérémie Decalf, Vincent Bondet, David Hunt, Gillian I Rice, Scott Werneke, Sarah L McGlasson, Marie-Alexandra Alyanakian, Brigitte Bader-Meunier, Christine Barnerias, Nathalia Bellon, Alexandre Belot, Christine Bodemer, Tracy A Briggs, Isabelle Desguerre, Marie-Louise Frémond, Marie Hully, Arn M J M van den Maagdenberg, Isabelle Melki, Isabelle Meyts, Lucile Musset, Nadine Pelzer, Pierre Quartier, Gisela M Terwindt, Joanna Wardlaw, Stewart Wiseman, Frédéric Rieux-Laucat, Yoann Rose, Bénédicte Neven, Christina Hertel, Adrian Hayday, Matthew L Albert, Flore Rozenberg, Yanick J Crow, Darragh Duffy
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
Neuron
Published
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Authors
Ira Espuny-Camacho, Amaia M Arranz, Mark Fiers, An Snellinx, Kunie Ando, Sebastian Munck, Jerome Bonnefont, Laurie Lambot, Nikky Corthout, Lorna Omodho, Elke Vanden Eynden, Enrico Radaelli, Ina Tesseur, Selina Wray, Andreas Ebneth, John Hardy, Karelle Leroy, Jean-Pierre Brion, Pierre Vanderhaeghen, Bart De Strooper
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Hum Mol Genet
Published
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Authors
Cynthia Sandor, Paul Robertson, Charmaine Lang, Andreas Heger, Heather Booth, Jane Vowles, Lorna Witty, Rory Bowden, Michele Hu, Sally A Cowley, Richard Wade-Martins, Caleb Webber
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Nature
Published
PLD3 gene and processing of APP.
Authors
Pietro Fazzari, Katrien Horre, Amaia M Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C Saido, Bart De Strooper
PLD3 gene and processing of APP.
Blood
Published
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.
Authors
David Kavanagh, Sarah McGlasson, Alexa Jury, Jac Williams, Neil Scolding, Chris Bellamy, Claudia Gunther, Diane Ritchie, Daniel P Gale, Yashpal S Kanwar, Rachel Challis, Holly Buist, James Overell, Belinda Weller, Oliver Flossmann, Mark Blunden, Eric P Meyer, Thomas Krucker, Stephen J W Evans, Iain L Campbell, Andrew P Jackson, Siddharthan Chandran, David P J Hunt
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.
Lancet Neurol
Published
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Authors
Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Genes Dev
Published
Synthetic lethality between PAXX and XLF in mammalian development.
Authors
Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson
Synthetic lethality between PAXX and XLF in mammalian development.
Nat Neurosci
Published
Neuronal activity enhances tau propagation and tau pathology in vivo.
Authors
Jessica W Wu, S Abid Hussaini, Isle M Bastille, Gustavo A Rodriguez, Ana Mrejeru, Kelly Rilett, David W Sanders, Casey Cook, Hongjun Fu, Rick A C M Boonen, Mathieu Herman, Eden Nahmani, Sheina Emrani, Y Helen Figueroa, Marc I Diamond, Catherine L Clelland, Selina Wray, Karen E Duff
Neuronal activity enhances tau propagation and tau pathology in vivo.
Lancet
Published
Alzheimer's disease.
Authors
Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier
Alzheimer's disease.