Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Nat Rev Neurosci

Published Nov 23, 2017

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Authors

Giles E Hardingham, Priit Pruunsild, Michael E Greenberg, Hilmar Bading

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Neurology

Published Nov 21, 2017

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

Authors

Philip S J Weston, Teresa Poole, Natalie S Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B Malone, R Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N Rossor, Jonathan M Schott, Henrik Zetterberg, Nick C Fox

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

PLoS One

Published Nov 16, 2017

Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.

Authors

Hideaki Suzuki, He Gao, Wenjia Bai, Evangelos Evangelou, Ben Glocker, Declan P O'Regan, Paul Elliott, Paul M Matthews

Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.

Neuron

Published Nov 15, 2017

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

Authors

Samuel J Barnes, Eleonora Franzoni, R Irene Jacobsen, Ferenc Erdelyi, Gabor Szabo, Claudia Clopath, Georg B Keller, Tara Keck

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

EMBO Mol Med

Published Nov 07, 2017

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Authors

Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert-Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie-Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Wellcome Open Res

Published Nov 02, 2017

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

Authors

Sarah McGlasson, Kristiina Rannikmäe, Steven Bevan, Clare Logan, Louise S Bicknell, Alexa Jury, , Andrew P Jackson, Hugh S Markus, Cathie Sudlow, David P J Hunt

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

J Neurosci

Published Sep 13, 2017

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Authors

Shlomi Haar, Opher Donchin, Ilan Dinstein

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Elife

Published Sep 12, 2017

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Authors

Nathan G Skene, Marcia Roy, Seth Gn Grant

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Nat Commun

Published Aug 18, 2017

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Authors

Laura McCulloch, Craig J Smith, Barry W McColl

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Neuron

Published Aug 02, 2017

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Authors

Hua Chai, Blanca Diaz-Castro, Eiji Shigetomi, Emma Monte, J Christopher Octeau, Xinzhu Yu, Whitaker Cohn, Pradeep S Rajendran, Thomas M Vondriska, Julian P Whitelegge, Giovanni Coppola, Baljit S Khakh

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Cell

Published Jul 27, 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Authors

Maria Szaruga, Bogdan Munteanu, Sam Lismont, Sarah Veugelen, Katrien Horré, Marc Mercken, Takaomi C Saido, Natalie S Ryan, Tatjana De Vos, Savvas N Savvides, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Nick C Fox, Carsten Hopf, Bart De Strooper, Lucía Chávez-Gutiérrez

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Elife

Published Jul 21, 2017

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Authors

Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Glia

Published Jul 19, 2017

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Authors

Yasmina Manso, Philip R Holland, Akihiro Kitamura, Stefan Szymkowiak, Jessica Duncombe, Edel Hennessy, James L Searcy, Martina Marangoni, Andrew D Randall, Jon T Brown, Barry W McColl, Karen Horsburgh

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Cell

Published Jun 01, 2017

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Authors

Nir Grossman, David Bono, Nina Dedic, Suhasa B Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S Boyden

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Sci Transl Med

Published May 31, 2017

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Authors

Qiaoqiao Shi, Saba Chowdhury, Rong Ma, Kevin X Le, Soyon Hong, Barbara J Caldarone, Beth Stevens, Cynthia A Lemere

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Nature

Published May 04, 2017

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Authors

Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies, David C Rubinsztein

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Sci Transl Med

Published May 03, 2017

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Authors

Bradley N Smith, Simon D Topp, Claudia Fallini, Hideki Shibata, Han-Jou Chen, Claire Troakes, Andrew King, Nicola Ticozzi, Kevin P Kenna, Athina Soragia-Gkazi, Jack W Miller, Akane Sato, Diana Marques Dias, Maryangel Jeon, Caroline Vance, Chun Hao Wong, Martina de Majo, Wejdan Kattuah, Jacqueline C Mitchell, Emma L Scotter, Nicholas W Parkin, Peter C Sapp, Matthew Nolan, Peter J Nestor, Michael Simpson, Michael Weale, Monkel Lek, Frank Baas, J M Vianney de Jong, Anneloor L M A Ten Asbroek, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Nigel Leigh, Hardev Pall, Karen E Morrison, Ammar Al-Chalabi, Pamela J Shaw, Janine Kirby, Martin R Turner, Kevin Talbot, Orla Hardiman, Jonathan D Glass, Jacqueline De Belleroche, Masatoshi Maki, Stephen E Moss, Christopher Miller, Cinzia Gellera, Antonia Ratti, Safa Al-Sarraj, Robert H Brown, Vincenzo Silani, John E Landers, Christopher E Shaw

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Nat Commun

Published May 02, 2017

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Authors

Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C Todd, Samuel Heron, Nóra M Márkus, Jamie McQueen, David W Hampton, Megan Torvell, Sachin S Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J A Wyllie, T Ian Simpson, Giles E Hardingham

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.